Therapeutic Effects Of S-TACE Combining With High-frequency Thermotherapy In Primary Hepatocellular Carcinoma

Objective:To analyze the therapeutic effects of S-TACE combining with high-frequency thermotherapy in patients with primary hepatocellular carcinoma(HCC).Methods:50 HCC patients were selected from January 2012 to February 2014,and were divide into 2-groups,group A was taken S-TACE alone,group B was underwent S-TACE combined with regional high-frequency hyperthermia.The changes of liver function,SIL-2R,VEGF,IL-6,COX-2 contents were determined in patients with HCC pre-and post-treatment.The score of KPS,survival time and side effects(such as fever,nausea,vomiting,abdominal distension,pain)were analyzed.Results:Compared with the pre-treatment,the liver of ALT,AST,TBIL and DBIL significantly increased post-treatment for a week in group A(P<0.05),but no significant differences in group B.The score of KPS were improved after 4 weeks treatment in both groups,but only in group B were significance differences(P<0.05).Compared with the pre-treatment,the VEGF,IL-2R and IL-6 contents were significantly decreased after 1st and 4th weeks treatment in the two group(P<0.05),the expression of COX-2 was increased in group A(P<0.05),but there was no change in group B.Compared with the 1st week after treatment,the IL-6 was significantly declined after 4th week in the two groups.The VEGF and SIL-2R contents was significant increased in group A(P<0.05),while dramatically decreased in group B after 4th week treatment(P<0.05).The incidence rate of side effects in group B was significantly lower than that the group A(P<0.05).2 year survival rate was significantly lower in group A than that the group B(P<0.05).Conclusion:1.STACE combined with regional high-frequency thermotherapy can increase the KPS,improve the quality of life,reduce side effects and prolong survival rate.2.The contents of serum VEGF,SIL-2R and IL-6 and tissue COX-2 may be related with the effects of the STACE and regional high-frequency thermotherapy.