The Clinical Research Of Traditional Chinese Medicine Combined Low Molecular Heparin Calcium In The Prevention Of Lower Extremity Deep Vein Thrombosis After Total Hip Arthroplasty

Objective: Using clinical control study observes the effect of Chinese medicine combined low molecular heparin calcium in the prevention of lower extremity deep vein thrombosis(DVT)after total hip arthroplasty to discuss its mechanism of action and safety exerting the features and advantages of Chinese medicine.To offer a reference of using the traditional Chinese medicine prevents the lower extremity DVT after total hip arthroplasty.Methods: Choosing the patients who were suffered from Osteonecrosis of The Femoral Head with unilateral total hip arthroplasty for the first time in the orthopaedics of traditional Chinese medicine hospital in henan province Between April 2015 and January 2016.The patients were randomized into experimental group and control group.The control group(30 cases):Using the low molecular heparin calcium(Wan Mai Shu)in subcutaneous injections;Experimental group(30 cases): On the basis of the control group,the experimental group take antithrombotic unclogged arteries soup orally using external acupoint sticking.To compare the indexes PT,APTT,FIB,D-dimer,incidence of postoperative venous thromboembolism,postoperative drainage volume,the appearance of the subcutaneous ecchymosis and thigh diameter changes of two groups of preoperative and postoperative on one day,seven days,fourteen days.The data obtained by SPSS18.0 statistical analysis.Measurement data be presented mean±standard deviation((?)±s).Using Analysis of variance is used to compare between measurement data set.Count data compared by c2 text.When P <0.05 for the difference is statistically significant.Results: There were three cases of postoperative DVT of 60 patients and the total incidence was 5% one case in the experimental group incidence 3.33% and in the control group there were two cases incidence 6.67%.The two groups in the incidence of DVT has no obvious difference(P>0.05).Laboratory indicators: two groups on postoperative one day(before taking medicine)PT and APTT were shorter than preoperative and the FIB,D-dimer level were higher than preoperative.After taking medicine comparing with the opposite one the contrast within group at each time point were statistically significant(P<0.05);Comparison between the two way in prolong PT,APTT and reducing D-dimer level the experimental group is better than that of control group(P<0.05)and other contrast have no obvious difference(P>0.05).Through observing the incidence of postoperative subcutaneous ecchymosis test group is less than the control group and the difference has statistical significance(P<0.05).Both groups of postoperative thigh diameter increased comparing with the preoperative one.The contrast between the two groups after seven days the experimental group is better than that of control group(P<0.05).As for the postoperative drainage volume experimental group had significantly less than the control group(P<0.05).Conclusion: Through the clinical observation research Chinese medicine combined low molecular heparin calcium can obviously prolong PT,APTT of patients after total hip arthroplasty reduce the FIB,D-dimer level and improve blood high condensation state so as to prevent the happening of the postoperative lower extremity DVT.Comparing with low molecular heparin calcium,Chinese medicine combined low molecular heparin calcium in prolonging PT,APTT and reducing D-dimer level is better than that of low molecular heparin calcium.In the effect of reducing postoperative drainage volume improving the limb swelling and reducing harmful bleeding the Chinese medicine combined low molecular heparin calcium has obvious advantages too.