| Objective To discuss the relationship of cyclophilin A(Cyp A) in postoperative restenosis of patients with coronary heart disease(CHD) after percutaneous coronary intervention(PCI),which can provide theorical and clinically basis for prevention and cure of restenosis by detecting the peripheral Cyp A before and after PCI.Methods This study enrolled 131 patients who had admitted in the cardiology, Second Affiliated Hospital, University of South China, between January 2014 and January 2015. Among them, 101 patients who had PCI were selected as the CHD group which was divided AMI(44), UAP(30) and SAP(27) group, and 30 patients with normal coronary angiography(CAG)were as the control group. CAG was re-examined within 12 months after the operation, and the patients were divided into the restenosis group and non-restenosis group according to the CAG results. ELISA was used to determine the peripheral Cyp A and hs-CRP levels in these patients in all groups before PCI and after PCI in 24 hours respectively,and the peripheral Cyp A was detecting again when CAG was re-examined in the CHD group.The conditions of restenosis within 12 months and the clinical and laboratory data were recorded and followed up. And all the collected data were analyzed with SPSS and Microsoft Excel.Results 1. Basic clinical data were compared between the CHD groups and the control group. There were statistical differences between SAP group,UAP group, AMI group and the control group in preoperative Cyp A and Hs-CRP(P<0.05), and the plasma concentration of the two indexes were followed: AMI>UAP>SAP>control group(P<0.05). Cyp A levels of each CHD group was higher after PCI compared with before the operation(P<0.05).2. The postoperative Cyp A levels within 24 hours(18.29 ± 1.49ng/ml),and Cyp A levels of re-examined the CAG(16.44 ± 1.09ng/ml)were higher than that of preoperative( 13.84 ± 0.46ng/ml) in restenosis group(P <0.05), but There were no significant differences in peripheral Cyp A of 24hours(14.99 ± 1.29ng/ml)and re-examined the CAG(14.03 ± 1.01ng/ml)compared with preoperative(13.73 ± 0.50ng/ml) in non-restenosis group(P>0.05). Compared with the non-restenosis group the restenosis group within 24 hours after PCI, re-examined the CAG Cyp A level were higher than that of postoperative Cyp A levels(P<0.05), but there were no statistical difference between the two groups in preoperative Cyp A levels(P>0.05).3. ROC curve analysis on the relationship between Postoperative Cyp A and hs-CRP levels and restenosis found that the values area under the curve(AUC) of Cyp A and hs-CRP were 0.832 and 0.733, and there was positive correlation between them(r=0.696, P<0.05). Compared with low postoperative Cyp A group, patients with high postoperative Cyp A levels( ? 15.20ng/ml) had poor prognosis(2c = 9.658, P = 0.002). Binary Logistic stepwise regression was applied and found that postoperative Cyp A was one of the independent predictors of restenosis.Conclusions 1. The peripheral CypA levels in CHD patients rises obviously, and being gradually increased with the severity of disease after the PCI.2. The serum Cyp A levels in CHD patients has obviously increased after the PCI, which is the higher, the more prone to restenosisthe in CHD patients.3. Postoperative Cyp A levels may be one reliable biochemical predictor for restenosis of CHD patients after the PCI. |
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