Application Of 3D-ASL Technique In Observation On Cerebral Blood Flow Changes In Early And Mid-stage Primary Open Angle Glaucoma

Objective:Based on Three Dimensional Arterial Spin Labeling(3D-ASL) was used to examine the cerebral blood flow(CBF)changes of cerebrum for patients with early and middle stage primary open-angle glaucoma(POAG) and to explore the characters of CBF changes and Central nervous system injury in early and middle stage POAG in order to providing a new thinking of preventing POAG.Methods: According to the inclusion and exclusion criteria of POAG, Seventeen POAG patients and seventeen gengder-age-matched healthy control were enrolled in the study. For each participant high-resolution structural brain image was acquired on a 3.0 scanner. CBF images were obtained after being preprocessed by SPM8. REST were used to analyze CBF changes of whole brain and correlation analysis between CBF changes and RNFL and MD.Result:1) whole brain CBF analysis:compared with control group,CBF is mainly decreased in POAG. The area include:right cerebellum, left superior occipital gyrus, right precentral gyrus, left cerebellum, right superior frontal gyrus, left fusiform gyrus, corpus callosum, left calcarine, the left parahippocampal. Increased CBF area:inferior frontal gyrus, caudate nucleus, orbitofrontal.2) correlation analysis:RNFL was shown positive correlation with right inferior temporal gyrus, left calcarine, right cerebellum and right occipital gyrus. It has positive correlation between MD and right superior frontal, right calcarine and left middle frontal.Conclusion:POAG in early and middle stage POAG could cause cerebral blood flow decrease,and these changes were positive correlation to RNFL and MD. Cerebral blood flow may be a potential biomarker for the brain involvement in glaucoma.