| Objective: This study investigated the effect of renal denervation(RDN) on aquaporins(AQP)in kidney.Methods: 12 adult Chinese Kunming dogs were randomly divided into RDN group and control group(6 for each group). The dogs in RDN group underwent bilateral RDN using radiofrequency ablation catheter, and radiofrequency catheter was positioned in bilateral renal artery without ablation in control group. The tissue levels of norepinephrine(NE) and AQP1-3 in kidneys were detected at 1 month, and blood pressure(BP) measurements were performed at baseline and 1 month.Results: Tissue levels of NE in RDN group were significantly lower than that in control group(554±119ng/g vs. 1171±434ng/g, P<0.01). The expression of AQP1-3 in renal cortex and medulla was decreased in RDN group than in control group. RDN also caused a substantial BP reduction(200.8±23.0/128.6±19.4 mmHg vs. 169.6±23.2/ 96.2±25.4 mmHg; P<0.01 for systolic BP, P=0.011 for diastolic BP).Conclusion: RDN substantially decreased the tissue levels of NE and AQP in dog kidney, and also decreased BP significantly, which might be implicated in the mechanism of BP reduction by RDN; Renal sympathetic nerve play a excitatory role in the regulation of AQP channels in the kidney. |
PDF Full Text Request