Study On Left Ventricular Rotation And Twist By Two-dimensional Speckle Tracking Imaging In Patients With Different Coronary Artery Disease

Objective To evaluate left ventricular rotation and twist in patients with different coronary artery disease at rest by 2D-STI.Methods 45 patients diagnosed coronary artery disease were included in the study and 35 healthy volunteers(N group) as control group. According to the result of selective coronary angiography, these patients were divided in two groups: LAD group and RCA group. Short-axis parasternal views were taken at the base and the apex of the heart. The two-dimensional speckle tracking technique was applied to analysis the rotation curves at apex and base, to measure Rendo, Repi, Rbulk and Tmural and to record the time to peak. And then Untw R, Ptw-bulk and the time to peak were calculated.Result(1)Compared with normal group, Rendo, Repi, Rbulk, Tmural and Untw R decreased significantly and the time to peak were delayed in apical level in patients with anterior descending branch stenosis(P<0.05).(2)Compared with normal group, Rendo, Repi, Rbulk, Tmural and Untw R decreased significantly and the time to peak were delayed in basal level in patients with right coronary artery stenosis(P<0.05).(3)For Ptw-bulk and the time to peak, there was no significant difference between LAD group and RCA group(P>0.05).(4)Rendo, Repi, Rbulk and Ptw-bulk were related to LVEF. Furthermore, Ptw-bulk had the highest relation to LVEF( r =0.68,P<0.01), followed by Rbulk of the apical level( r =0.43,P<0.01). But Tmural was not related to LVEF.Conclusion Different coronary artery stenosis affect differently in basal and apex level. LV twist is related to LVEF. 2D-STI can evaluate LV twist accurately in patients with different coronary artery disease.