| Objective 1.To know the etiology constitution and trends of liver diseases in the past 20 years in comprehensive hospital.2.Analyze clinical features and diagnosis ideas of patients with blood system diseases performed as liver diseasesMethods 1.Retrospective observational analysis was performed on 7570 cases who were admitted to inpatient clinic for liver diseases in Tongji hospital from Jan 1995 to Dec 2014,summarizing the diagnosis and disease spectrum of normal liver diseases. 2.Analyze a few cases of blood system diseases performed as liver diseases in detail,summarize the clinical features and treatments ideas.Results 1.Out of the 7570 cases,common diagnosed diseases were viral hepatitis(4930 cases,65.13%), among which hepatotropic vivus took 4886 cases,with a percentage of 64.54%,non-hepatotropic virus 44 cases, 0.58%.in hepatotropic virus,HAV 209 cases,2.76%; HBV 2726 cases, 36.01%;HCV 459 cases,6.06%;HEV 926 cases,12.23%. Co-infectious of hepadnavirus were easy to see(561 cases,7.41%),viral hepatitis B co-infected with hepatitis E were 434 cases(77.36%),and the percentage of this kind of disease was increased(68.13% vs 86.11%); autoimmune diseases 4.39%(332/7570), AIH1.66%(126/7570), PBC1.31%(99/7570),, overlap syndrome induced liver diseases0.32%(24/7570), other autoimmune diseases(such as SLE, dermatomyositis)80cases,1.06%; drug-induced liver injury 2.84%(215/7570); fatty liver2.54%(192/7570), Schistosome liver diseases1.16%(88/7570),Genetic metabolic liver diseases2.11%(160/7570),Vascular diseases0.13%(20/7570). however, 9.1%(689/7570) were discharged without final diagnoses. 2.During Jan 1,1995-Dec 31,2004 and Jan1,2005-Dec 31,2014,the diagnosis of liver diseases were changed. Hepatitis patients were declined according to the statistics,77.61% vs 59.19%,p<0.01. Among the single-infectious hepatotropic virus hepatitis, viral hepatitis C and hepatitis E have grew, the percentage were 2.24% vs 15.56%(p<0.01)and 18.61% vs 23.07%,(p<0.05). the percentage of viral hepatitis B and viral hepatitis A were declined,the percentage were 68.14% vs 60.01%(p<0.05) and 10.7% vs 1.36%(p<0.01). In the past 10 years,the percentage of autoimmune diseases has increases,the percentage were 0.82% vs 6.08%,p<0.01. 3.Diseases of blood system were 35 cases(0.46%) in total, the number of single blood system diseases was 27,blood diseases co-infected with viral hepatitis was 8. Conclusion 1.Liver diseases occupied a certain proportion in inpatients of our department,which is harmful for the people,especially viral hepatitis B and E. 2.The epidemiological of liver diseases was changing. viral hepatitis was decreased while noninfectious diseases were increased, so did complicated liver diseases. Doctors of Higher hospital will face more challenges of complicated liver diseases. 3.in patients with complicated liver diseases,although hematological system diseases only took 0.46%,but it's easy to misdiagnose,so, it should be taken into consideration. |
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