Correlation Analysis Of Connective Tissue Growth Factor With Pleural Thickening

Objective: To investigate the expression of connective tissue growth factor(CTGF) in pleural effusion and serum of patients with different nature of pleural effusion, and to investigate whether they are involved in the formation of pleural thickening and the possible role of connective tissue growth factor.Methods:Collected 126 cases of patients with pleural effusion and divided into 4 groups, respectively is the group of tuberculous pleurisy, parapneumonic effusion, malignant pleural effusion and transudate group. Samples of peripheral venous blood and pleural fluid and blood samples of coagulation and blood routine test and record the content of fibrinogen, and the white blood cell and neutrophil absolute numerical value, the platelet count; in water samples were in conventional water and in water biochemical detection and recorded the number of cell, protein content, sugar content, LDH and ADA numerical. In order to further study of CTGF and pleural thickening and the formation of relationships, the four groups of the enzyme linked immunosorbent assay to detect serum protein and pleural effusion of CTGF expression. All measurement data are using s, statistical processing using spss19.0 statistical software package, the comparison of multi group measurement data using ANOVA one-way test. The comparison of measurement data using t test, count data using X2 test. CTGF and other indicators of the correlation analysis using the Pearson method. The accuracy of pleural thickening was assessed using the receiver operating curve(ROC) and the area under the curve(AUC). The difference was statistically significant with P < 0.05.Results: 1. Inflammation and tuberculosis group and tumor group and heart failure transudate group pleural hypertrophy population proportion for 38.24%, respectively, 55.56% and 26.67% and 3.85%(P < 0.05).Table 2. 2. Serum CTGF expression values were determined in the inflammatory group, tuberculosis group and tumor group and transudate heart failure group were 196.52 + 118.21262.00 + 12.958, 4.574 + 29.27 and 75.67 + 5.824(P > 0.05).Figure 1. 3. In water CTGF expression values in the inflammatory group, tuberculosis groupand tumor group and transudate heart failure group were 141.33 + 115.93317.78 + 150.10 and 94.68 + 69.48, 50.70 + 34.33(P < 0.05).Figure 2. 4. Comparison of clinical biochemical indexes between CTGF level and tuberculosis group: the course of disease, the proportion of pleural effusion, the number of pleural effusion cells, the content of pleural effusion and serum fibrinogen were correlated(P < 0.05).Table 5. 5.Tuberculosis group occurrence of pleural thickening and no cases of pleural thickening in clinical science data comparing the two groups in pleural effusion cells number and pleural fluid protein content, as well as the value of pleural effusion and serum CTGF with significant difference(P < 0.05).Table 6 6. In water of CTGF and tuberculosis pleural effusion thoracic cell water content measurement of ROC curve, curve of CTGF area is 0.847 P = 0.016, pleural effusion cell number under the curve area is 0.785 P = 0.048, pleural fluid protein content under the curve area is 0.833 P = 0.021.Figure 3.Conclusion: The highest probability of pleural thickening and fibrosis occurred in patients with tuberculous pleural effusion was 55.56%(P < 0.05). In pleural effusion in determination of CTGF expression value in the diagnosis of tuberculous pleurisy was the highest 317.78 + 150.10(P < 0.05), and determination of CTGF levels and Tuberculo pleurisy duration of disease in patients with pleural effusion, water in proportion, cell numbers in water, in water content of protein, serum fibrin original content and many other and index correlated(P < 0.05). This study thoracic water CTGF cut-off value is 163.03pg/ml when an auroc of equal to 0.847, sensitivity 88.9% for the prediction of pleural thickening and 75% specificity...