| Objective: We aimed to explore the risks of hyperlipidemia in differentiated thyroid cancer(DTC) patients when their thyroid hormones were abnormal, emphasizing the risks from different genders.Methods: The study included 352 DTC patients(263 women, 49.17±12.97 years; 89 men, 47.43±12.30 years) who were ready to receive 131 I therapy, as well as 352 healthy participants. In DTC group, 157 patients had adequate information to evaluate changes of serum lipid levels before and one-month after 131 I therapy(under thyroxine therapy). We assessed the relationships between thyroid stimulating hormone(TSH) and lipids in different genders. All participants were divided into 3 subgroups according to TSH levels, ? 5 ?IU/m L, 5-30 ?IU/m L, and > 30 ?IU/m L. The diagnostic criteria for dyslipidemia were: total cholesterol(TC) ? 5.18 mmol/L, triglycerides(TG) ? 1.70 mmol/L, high-density lipoprotein-cholesterol(HDL-C) < 1.04 mmol/L, low-density lipoprotein-cholesterol(LDL-C) ? 3.36 mmol/L. Independent samples t-test was used to compare parameters' concentrations between groups. Pearson bivariate correlations were calculated. Odds ratio(OR) for hyperlipidemia was calculated by binary logistic regression models.Results:1. Serum TC, TG, LDL-C and HDL-C levels in two groups were as follows(mmol/L): in DTC group 6.63±1.39, 2.25±1.82, 4.16±1.15, and 1.59±0.44; in control group 5.04±0.97, 1.46±0.92, 2.85±0.84, and 1.56±0.40. There were significant differences of TC, TG and LDL-C between groups(P<0.05).2. Levels of the above indices before and after one-month of thyroxine therapy were: before therapy 6.96±1.29, 2.25±1.40, 4.40±1.11, and 2.69±12.80; after therapy 5.19±1.10, 1.63±1.05, 3.09± 0.98, and 1.40±0.52. TC, TG and LDL-C had statistical significance(P<0.05).3. In male, the coefficients of TSH with the above parameters were 0.50(P<0.05), 0.28(P<0.05), 0.52(P<0.05), and 0.01(P=0.864). In female, the coefficients were 0.55(P<0.05), 0.29(P<0.05), 0.52(P<0.05) and 0.10(P<0.05).4. From binary logistic regression(using subgroup 1 as reference) showed, in male, ORs(95% confidence interval) for abnormal TC, TG, LDL-C and HDL-C in subgroup 2 were 3.30(0.78-13.92, P=0.10), 1.35(0.34-5.30,P=0.67), 2.63(0.67-10.29?P=0.17) and 0.72(0.13-3.91, P=0.70), the ORs in subgroup 3 were 9.40(4.17-21.15, P<0.05), 1.83(0.92-3.63, P=0.09), 9.60(4.53-20.35, P<0.05) and 0.50(0.21-1.19, P=0.12); in female, the parameters in subgroup 2 and 3 were 4.6(2.05-10.3, P<0.05), 1.85(0.88-3.88, P=0.11), 2.52(1.27-4.97, P<0.05), 1.08(0.23-5.13, P=0.92) and 13.12(7.74-22.25, P<0.05), 5.50(3.50-8.65, P<0.05), 12.98(8.11-20.78, P<0.05), 0.68(0.25-1.83, P=0.44) respectively.Conclusion: Our results showed that the danger for dyslipidemia increased obviously in DTC patients, who, after thyroidectomy, were in severe hypothyroidism conditions. More importantly, female patients had higher risk than male patients in the same serum TSH levels. |
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