Study On ¹⁸F-FDG PET/CT Imaging Of Lung Space Occupying Leisions Compared With Thin Slice Thickness CT

Objective 1.Through a number of collected sample analysis to explore functio nal metabolism and morphological characteristics in 18F-FDG PET/CT combined with t hin slice thickness CT of primary lung cancer.then compared with pathological results.To assess the value of space-occopying lesions in the lungs of benign and maligant w ho undergoing PET/CT in combination with thin slice thickness CT.2.Explore validity and its influencing factors in differential diagnosis of benign and malignangt lung lesi ons in SUV values and the two-phase SUV.Get the best SUV values to identify beni gn and malignangt lung lesions.3.Explore the relationship between leision size and pat hological type.Methods 100 patients who visit ningxia medical hospital from 2011.6 to 2015.10 because of space-occopying lesions in lungs follow up surgical treatment,pathological biopsy or clear pathological results were reviewed retrospectively, Find the PET and CT imaging examination data. Use SPSS 17.0 for statistical analysis. To assess the value of diagnosis of benign and malignant space-occupying lesion in lung between PET/CT, thin slice thickness CT and SUVmax2.5 as threshold respetively. Use pathological results as the gold standard. Compare the differential in sensitivity, specificity and accuracy in diagnosis of benign and malignant space-occupying lesions in lung. SUV of different pathological type was compared using independent-sample t-test. SUV of different pathological type, tumor diameter was compared using one-way ANOVA. Compare consistency using kappa analysis?inspection level a=0.05?Results 1.Thin slice thickness CT show lung space-occupying lesion signs in morphology such as typical nodular with leaflet, burr sign around, vessel convergence sign is superior to PET/CT. The sensitivity, accuracy, Specificity,PPV and NPV of PET/CT to diagnose space-occupying lesion in lung is 91.6% ? 93.7% ? 92% ? 98.7% ? 68.2% respectively;youden inedx is 0.85.The sensitivity, accuracy, specificity PPV and NPV of thin slice thickness CT to diagnose space-occupying lesion in lung is 92.8%?68.7%?89%?93.9%?64.7% respectively,youden index is 0.61; The sensitivity, accuracy, specificity PPV and NPV of PET/CT combined thin slice thickness CT to diagnose space-occupying lesion in lung is 98.8%?93.7%?98.0%?98.8%?93.7% respectively,youden index is 0.92.The sensitivity, accuracy, specificity PPV and NPV of vivusal analysis is 91.6%?31.2%?82%?87.5%?41.6% respectively,youden index is 0.22.The sensitivity of PET/CT to diagnose lung cancer is higher than thin slice thickness CT,( ?2=4.89,P=0.02);The sensitivity and NPV of PET/CT combined thin slice thickness CT is higher than PET/CT(?2=4.72?5.63,P=0.03?0.02);The accuarcy and NPV is higher than thin slice thickness CT(?2=6.66?4.16,P=0.01?0.04). 2.The consistency of PET/CT combined thin slice thickness CT is best,which k=0.92,accuracy is 98%.The consistency of PET/CT and thin slice thickness CT is better,which k=0.74,0.60 respectively,accuarcy is 92%,89%.however,The consistency of SUVmax2.5 as threshold is worst,which k=0.25,accuarcy is 82%.SUVmax?delay SUVmax and ?SUVmax increase increases as diamatere and clinical stage increase.3. SUV of malignant and benign space-occopying lesions in lung was statistically significant(malignant 9.08±5.83, benign 3.23±3.04,P?0.001), SUV of difference pathological type is statistically significant,(squamous carcinoma 10.99±3.96, adenocarcinoma 8.18±7.18, Other types of cancer 6.12±3.51),LSD-t we found that SUVmax?delay SUVmax and ?SUVmax of squamous cancer is higher than adenocarcinoma and other types of cancer(0.03?0.01?0.28;0.002?0.002?0.25;0.00?0.00?0.14);In different histology cancer,the better differentiation,the lower SUVmax?delay SUVmax and ?SUVmax. 4. The best SUV Suitable for diagnosing benign and malignant space-occupying lesion in lung is 5.65,where best sensitivity?specificity and accuarcy degree can be obtained(sensitivity73.8%, specificity 87.5%,accuary76%,AUC was 0.81), The best delay SUV suitable for diagnosing benign and malignant space-occupying lesion in lung is 7.65,which best sensitivity?specificity and accuarcy degree can be obtained(sensitivity72.6%, specificity 87.5%,accuarcy75%,AUC was 0.83). The best ?SUVmax suitable for diagnosing benign and malignant space-occupying lesion in lung is 0.35,which best sensitivity?specificity and accuarcy degree can be obtained(sensitivity94%, specificity 56.3%,accuarcy86%,AUC was 0.80).Conclusions 1. The sensitivity of PET/CT to diagnose lung cancer is higher than thin slice thickness CT;The sensitivity and validity of PET/CT combined thin slice th ickness CT is higher than PET/CT;The accuarcy and NPV is higher than thin slice thi ckness CT.2. The consistency of PET/CT combined thin slice thickness CT is best,ho wever,the consistency of SUVmax2.5 as threshold is worst.The SUVmax?delay SUVm ax and ?SUVmax increased with larger diamete.3. SUVmax?delay SUVmax and ?S UVmax of squamous is higher than adenocarcinoma and other types cancer. SUVmax?delay SUVmax and ?SUVmax with poor differentiation of cancer is higher than well differentied cancer.4.The best SUVmax?delay SUVmax and ?SUVmax suitable for d iagnosing benign and malignant space-occupying lesion in lung is 5.65?7.65 and 0.35 r espectively.