Analysis Of Clinical Effects Of Laparoscopy Combined With Gonadotropin-releasing Hormone Agonist On Deep Infiltrating Endometriosis

Objective:To investigate the effects of laparoscopy combined with gonadotropinreleasing hormone agonist(GnRH-a) in the treatment of deep infiltrating endometriosis(DIE).Methods:From January 2010 to October 2014,a total of 48 patients with DIE underwent laparoscopy in the Department of Gynecology,Affiliated Hospital of Ningxia Medical University.All the patients were performed laparoscopic surgery and confirmed by pathology.They were divided into GnRH-a group(n =22)and control group(n =26)according to patients?different treatment after their surgeries.GnRH-a group were treated by laparoscopy combined with GnRH-a and received 3-6 courses of GnRH-a,3.75 mg per time,every 28 days.Control group received laparoscopy only.The clinical effects,recurrence rate,pain relief rate were statistically analyzed.Results:1.From 2010 to 2014,the DIE patients with surgeries increased year by year.2.The preoperative diagnosis rate is in a upward trend.3.The NRS score of two groups without significant difference.4.The total effective rates of GnRH-a group and control group were 86.4%(19/26),61.5%(16/26),respectively,with significant difference(P < 0.05).The recurrence rates of GnRH-a group and control group were 4.6%(1/22),30.8%(8/26),respectively,with significant difference(P<0.05).The dysmenorrhea relief rates,dyspareunia relief rate,chronic pelvic pain relief rate and the total pain relief rate of GnRH-a group and control group were respectively,with significant difference(P <0.05).5.Side effects like menopausal syndrome may appear after using GnRH-a and disappear when the treatment is stop or the patients accept estradiol patch.Conclusion:Compared with laparoscopy use only,laparoscopy combined with GnRH-a could increase the rate of the total clinical effects and pain relief rates,and reduce the recurrence rate.