Prognostic Value Of Preoperative Lactate Dehydrogenase And Alkaline Phosphatase Levels In Patients With Pancreatic Cancer

Objective:To explore the prognostic value in patients with pancreatic cancer and to find out the effective supplement for clinic practical.Methods:Totally 94 clinical cases from January 2013 to July 2015 were retrospectively analyzed in the Sir Run Run Shaw Hospital of Zhejiang University School of Medicine.The Chi-square test was used to analyze the relationships between lactate dehydrogenase(LDH),alkaline phosphatase(ALP)and clinical characteristics.Prognostic factors were studied by multivariate analyzed with Kaplan-Meier estimation and COX proportion hazards survival model.Results:In our study,lymph node invasion and positive margin have relation with LDH(p<0.05).TNM stage and poor differentiated have relation with LDH/ALP(p<0.05).Median survival and one year survival rate are decreased in patient with positive carbohydrate antigen 19-9,LDH,ALP,poor differentiated,TNM stage,margin condition.Multivariate revealed that independent prognostic factors were carbohydrate antigen 19-9,LDH,ALP,poor differentiated,TNM stage,margin condition.Conclusion:The prognosis of patients with pancreatic cancer is determined by multiple factors,LDH/ALP,Radical resection,TNM stage and pathological differentiation grade influences the survival time of pancreatic cancer.Therefore,we conclude that the preoperative LDH and ALP values are prognostic factors for PADC.