The Relevance Of Research Between The TCM Syndrome Of NAFLD And Laboratory Index、B-Ultrasound Grade And FAI

Objective :To discussed the changeful rules of serum biochemical indicators in different types and deepen the understanding of Nonalcoholic Fatty Liver Disease by analyzing The Chinese Medicine Differentiation of Symptoms and Signs for Classification of Syndrome Type of NAFLD and serum biochemical indicators.Methods: By surveying the 210 cases of Nonalcoholic Fatty Liver Disease patients and 100 healthy people which are collected up from November 2016 to February 2017,in Wuhan Union Hospital Physical Examination Center.None of patients had particular previous medical history.I recorded the results of serum biochemical parameters,name,sex,age,height,body weight,body mass index(BMI),dietaryhabits,exercise,Liverfunction(ALT、AST、ALP、GGT),renal function(BUN、Cr、UA),ultrasound results,Fibro Touch check fat attenuation parameter values(FAI),liver fibrosis assessment value and so on,and given the 210 cases of non-alcoholic fatty liver in patients with syndrome differentiation based on the consensus that Chinese and Western medicine diagnosis and treatment of NAFLD which in the 2011.Used the 16.0statistical methods to analyze and deal with the results.Results:Based on the 210 cases of patients with nonalcoholic fatty liver disease patients and the information of 100 healthy patients,the serum biochemical indicators and Fibro Touch values and ultrasonic severity classification,statistical results are as follows:(1)the relationship of Nonalcoholic fatty liver disease among The Chinese Medicine Differentiation of Symptoms and Signs for classification of Syndrome and the sex ratio and age has no statistically significant differences,but has differences statistically significant in BMI(P<0.05).But the ratio of the210 patients with nonalcoholic fatty liver disease in men is significantly higher than female,male accounted for 71.9%.Between nonalcoholic fatty liver diseasegroup andnormal controlgroup,therewas nostatistically significant difference between sex and age.(2)Different syndrome types and biochemical indicators change rule:each group biochemical indexes of ALT,AST,GGT,TBIL,DBIL,CHOL,TG,FAI,liver fibrosis forecasts are different.Syndrome of intermingled phlegm and blood stasis is always associated with elevated LDL,Phlegmy wet resistance syndrome often accompanied by the rise of UA.Hot and humid intrinsic group often accompanied by the rise of bilirubin.Among the210 patients with nonalcoholic fatty liver disease,Mild fatty liver in depression and qi stagnation type accounted for 81.8%,moderate fatty liver in Phlegmy wet resistance syndrome accounted for33.3%,severe fatty liver in Turbid Phlegm and Blood Stasis accounted for 52.2%.(4)Different ultrasonic classification of each index change rule,the results of ALT,AST,GGT,CHOL,TG,FAI,FBG,BUA,BMI,and liver stiffness values in moderately and severe group were relatively increased Compared with mild group.(5)Spearman correlation analysis results:rTG>r肝硬度值>rFAI>rAST>rALT>rCHOL>rGGT>rTBIL(P<0.05),to explain ALT、AST、TBIL、GGT、BMI、CHOL、TG、FAI in all pattern of syndrome are better than other indicators.TCM syndrome type has a positive correlation with ALT、AST、TBIL、GGT、BMI、CHOL、TG、FAI result,At the same way,has a negative correlation with HDL.(6)Analysis the FAI and ultrasonic result has a significant linear correlation,r=0.887,and the use of((ROC curve)evaluation Fibro Touch diagnosis of fatty liver area under the ROC curve is 0.946,95%CI is between0.917 and 0.974,Fibro Touch tests the NAFLD compared with ultrasound technology,high accuracy,can be used as a new technology of clinical evaluation of NAFLD.FAI exist differences between different TCM syndrome types at the same time,FAI value assessment can be used in the TCM syndrome differentiation of nonalcoholic fatty liver disease.(7)Based on nonalcoholic fatty liver disease group and normal control group binary multiariable Logistic regression analysis of high blood triglycerides,high cholesterol,high uric acid hematic disease,high blood sugar and BMI were the main risk factors of nonalcoholic fatty liver disease,for the above lifestyle risk factors for improving and enhancing the physical exercise is particularly important.Conclusion:the liver function,blood lipids,fatty liver ultrasound grading,FAI values of Nonalcoholic fatty liver in the TCM syndrome types,has certain change rule,to provide objective index for TCM syndrome differentiation,deepen the understanding of nonalcoholic fatty liver disease in TCM.