Research On Correlations Between NAFLD Syndrome Types In Traditional Chinese Medicine And GGT With Its Fractions

Objective:Large numbers of literatures show that current reaserches on TCM syndrome type mainly including the relationship between type of syndrome and liver function, blood lipids, liver fibrosis, blood rheology and physical factors, very few from inflammation, oxidative stress level. So we choose GGT and its components (GGT2, GGT3, GGT6)as the main observation index closely related with the disease inflammation. To explore the relationship between the syndromes of TCM and pathogenesis of modern molecular biology foundation which has important significance.Methods:A questionnaire survey was conducted on 281 patients with nonalcoholic fatty liver disease, and collected related data. The observed contents includs:sex, age, height, weight, liver function (ALT, AST, GGT), serum lipid (TC, TG, HDL-C, LDL-C), fasting blood glucose, ultrasonic examination; detect GGT components (GGT2, GGT3, GGT6); filling in the TCM syndrome integral table, according to Consensus opinion on traditional Chinese medicine and Western Medicine setted in 2011, determine the TCM Syndrome Types in patients. Analysis the revelance of GGT components with TCM Syndrome Types.Results:1.281 patients in total, including 232 males and 49 females. the high risk age was from 30 to 60, trend of incidence age of patients with NAFLD gets younger. 2.NAFLD is common in people with overweight and obesity, overweight patients accounted for 80.4%, which accounted for the largest proportion.58% of the NAFLD patients which BMI significantly increased. Some NAFLD patients had no significant increase in BMI, accounting for 19.6%.3.137 patients with hypertension,41 with diabetes and dyslipidemia in 174 cases, the proportion was 48.7%,14.5%,61.9%.4. In 281 patients, ten kinds of TCM syndrome type occupied ratio from high to low in order were:obstruction of liver fire, liver stagnation and spleen deficiency and dampness heat accumulation, stagnation of the liver qi, wet turbidity, liver stomach disharmony, spleen deficiency and dampness resistance, internal heat due to yin deficiency, Yin deficiency of liver and kidney, liver fire flaming and a small number of cases unlicensed discernible. The liver fire syndrome, accounted for 23.1%.5. There was no significant difference of liver fire, liver stagnation and spleen deficiency and dampness heat accumulation, stagnation of the liver qi, wet turbidity stop of the five groups of syndrome type in terms of ALT, AST, TG, TC, HDL-C, LDL-C, and the differences between each components of GGT has statistical significance (P=0.041). 6.Five groups of syndromes, the relative concentration of damp heat accumulation group GGT2, GGT3 and GGT6 distribution, the difference between GGT2 index and the card type was significant, F=2.565, P= 0.041, differences between the rest of the GGT3, GGT6 each index card type had no statistics.Conclusion:1.Nonalcoholic fatty liver disease occurs in overweight and obesity people which are more concentrated in the 30-60 years old, male is more than female. 2.NAFLD patients combined with dyslipidemia account for the highest proportion.3. Among all the TCM syndrome types, liver Depression Transforming is the most common type.4.Three GGT componts has the closest relationship with damp-heat Accumulati type,while GGT2 has the relationship with all five types.