Effect Of Gan Ning Fang On Celluar Immune Function Of Patients With Chronic Hepatitis B

Objective: To observe the changes of CD³⁺?CD⁴⁺?CD⁸⁺ 's percentage?CTL? IL-2?IFN-??IL-6 and IL-10 in Peripheral blood of patients with chronic hepatitis B after Gan Ning Fang therapy and explore the effect of Gan Ning Fang therapy on celluar immune function.In the end,try to predict effectiveness of Gan Ning Fang therapy.Methods: With random number table grouping method,would meet the standard set of 66 cases were divided into two groups,treatment group 33 cases and control group 33 cases.the two groups were with the basic drug which profess to convinced Entecavir?National Drug Approval No.H20100019?,the drug provided by the company of Jiangsu zhengda tianqing,0.5mg each time,once a day,3 months for a course,a total of 2procedures,while treatment group profess to convinced Gan Ning Fang at the same time,100 ml each time,twice a day,and the control group simply professing to convinced Entecavir,before treatment and in third month,sixth month and sixth month after treatment,observation the changes of T lymphocyte subsets(CD³⁺?CD⁴⁺?CD⁸⁺)?IFN-??IL-2?IL-10?IL-6?CTL?HBV-DNA?HBe Ag?ALT?AST.Results:1.The comparison on the curative effect of TCM syndrome and TCM symptom score :The comparison between the two groups after treatment has a significant difference?P<0.05?.2.Comparison between the pre-treatment and pro-treatment,The treatment group of CD⁴⁺ ? CD⁸⁺ has a significant difference?P < 0.05?,comparison between the two groups after the treatment,which has a significant difference?P < 0.05?,while comparison between pre-treatment and pro-treatment,The two groups of the CD³⁺ hasn't significant difference?P>0.05?,comparison between the two groups after the treatment,The two groups of CD³⁺ hasn't significant difference?P >0.05?.3.Comparison between the pre-treatment and pro-treatment,The treatment groups of CTL has a significant difference?P<0.05?,comparison between treatment group and control group after the treatment,which has a significant difference?P<0.05?.4.Comparison between the pre-treatment and pro-treatment,The treatment groups of IFN-? has a significant difference?P<0.05?,while the treatment group of IL-2 hasn't significant difference?P>0.05?,comparison between treatment group and control group after the treatment,the two groups of IFN-? hasn't significant difference?P<0.05?The two groups of IL-2 hasn't significant difference?P > 0.05?.5.Comparison between the pre-treatment and pro-treatment,The treatment group of IL-6?IL-10 has a significant difference?P < 0.05?,comparison between treatment group and control group after the treatment,The two groups of IL-6?IL-10 has a significant difference?P<0.05?.6.Comparison between the two groups after the treatment,the HBe Ag negative conversion rate hasn't significant difference?P > 0.05?,the two groups of HBV-DNA negative conversion rate,compared with control group after the treatment,which has a significant difference?P < 0.05?.7.Comparison between treatment group and control group after the treatment,The two groups of ALT ? AST have a significant difference?P < 0.05?,comparison between the pre-treatment and pro-treatment,The treatment group of ALT ? AST have a significant difference?P<0.05?.Conclusion?s?:Gan NingFang play a role through increasing CD³⁺?CD⁴⁺?CD⁸⁺ 's percentage ? the activity of CTL cells ? the secretion of IFN-?,meanwhile,through reducing IL-2 or IFN-?secreted by Th1 cells can inhibit humoral immunity's hyperfunction,these can improve celluar immune function.Because it has advantages in anti-inflamatory and protecting liver,therefore Gan Ning Fang can protect hepatic cells from damage although in the case the antiviral of celluar immune function has improved,and then maked the symptom and syndrome of TCM as well as prognosis better,eventually get certain control the disease of CHB's progress.