Expression Of IL-33 In Pancreatic Cancer And Its Clinical Significance

Objective:To investigate the expression of IL-33 in tumor tissues,paracancerous tissues and normal tissues of pancreatic cancer patients,and to explore the correlation between the expression of IL-33 and the clinicopathological parameters of pancreatic cancer.Methods: The relative expression of IL-33 mRNA in tumor tissues,paracancerous tissues and normal tissues of pancreatic cancer was detected by Quantitative Real-time PCR.At the same time,the expression of IL-33 in tumor tissues,paracancerous tissues and normal tissues were verified by immunohistochemistry analysis.To analyze the relationship between the age,sex,tumor size,differentiation,TNM stage,lymph node metastasis,local invasion and other clinical pathological parameters.Results: The qPCR results by statistical analysis showed that the expression of IL-33 mRNA in paracancerous tissues was the highest,normal tissue middle and tumor tissues was least;Immunohistochemical results showed that IL-33 expression was highest in paracancerous tissues,the expression of IL-33 was in the middle in normal tissue,and the expression of IL-33 in tumor tissues was the least;In paracancerous tissue,IL-33 expression and lymph node metastasis,local invasion was significantly correlated(P?0.05),and pancreatic cancer patients with gender,age,tumor size,degree of differentiation,TNM staging without significantly correlated(P>0.05).Conclusion:The expression of mRNA IL-33 was the highest in paracancerous tissues,the expression in normal tissue was in the middle,and the least in tumor tissues,IL-33 played a anti-tumor role in pancreatic cancer.In paracancerous tissues,the expression of IL-33 was negatively correlated with lymph node metastasis and local invasion of pancreatic cancer.The expression of IL-33 was not related to the age,sex,tumor size,degree of differentiation and TNM stage.