Analysis Of The Correlation Factors And The Clinical Value Of Gleason Score In Patients With Prostate Cancer After Operation

Objective Prostate cancer(Prostate Cancer,PCa)has become a common clinical malignant tumor,serious harm to male health and quality of life.The transrectal prostate biopsy as the gold standard in the diagnosis of prostate cancer.Pathological grade using the Gleason standard for evaluation,determine the grade Gleason score for prostate cancer staging,diagnosis and treatment scheme selection and prognosis evaluation,but we often find that puncture biopsy and postoperative pathological Gleason score is often inconsistent,based on the results of clinical PCa patients the biopsy and postoperative pathology.The related factors of Gleason score were analyzed,which could be used as a guide for the staging,grading and treatment of prostate cancer patients.Methods Of the 106 cases in our hospital in 2012 02 months to October 2014 underwent laparoscopic radical prostatectomy for prostate cancer patients,all patients were completed in June after the prostate biopsy,the clinical data of 106 cases were analyzed retrospectively.106 cases of puncture and postoperative pathological results after the puncture,compared with postoperative Gleason score.The patients were divided into group,puncture and postoperative Gleason score were classified into group consistent statistics and calculate 106 patients age,body mass index(body mass,index,BMI,t PSA)before puncture,before The volume of the prostate,PSAD(PSA density),puncture and operation time,and the time of operation were calculated,and the influence of the above indexes on the Gleason score was calculated.Results 1.The postoperative pathological Gleason score was higher than that of the patients with pathological Gleason score of 56 cases(53%).The postoperative pathological Gleason score and the Gleason score were similar in 50 cases(47%).2.Comparison of patients with a Gleason score of less than 7 and greater than or equal to a score of 7,The proportion of postoperative Gleason score was higher,were 59%and48%.The difference was statistically significant(P<0.05).3.There was no correlation between age,body mass index(BMI),puncture and operation time and Gleason score and postoperative Gleason score(P>0.05).4.There was a significant correlation between PSA,FSAD,PSAD and postoperative Gleason score compared with the elevated Gleason score(P<0.05).5.At the same time,postoperative Gleason score,postoperative Gleason score was higher than that of the patients with elevated Gleason score after operation,the patients with Gleason score were more difficult,the operation time was prolonged,and the prognosis was worse.Conclusion There were some differences in the Gleason score between the puncture and postoperative pathology,especially when the Gleason score of the puncture biopsy was <7,the difference between the two groups was large,the concordance rate was low,and the Gleason score was often underestimated,Prostate volume,t PSA,FPSA,FPSA/t PSA are the factors that influence the inconsistency between the two groups,but the age,body mass index,puncture and operation interval are not significantly correlated with the two.