Study On The Synthesis Of Gemini Quaternary Ammonium Salt Bactericide Decamethoxin And Study On The Design,Synthesis And Bioactivity Of Tacrine Derivatives Cholinesterase Inhibitors

The First Part:Sterilizing agent can be divided into oxidizing sterilizing agent,non-oxidizing sterilizing agent and fluorine-containing compound of new sterilizer.Non-oxidizing sterilants are mainly quaternary ammonium salt,quaternary phosphonium salt,heterocyclic compounds and organic aldehydes,quaternary ammonium salt is the most widely used class of sterilizers,it was used as a sterilization in the 50s of last century,there are hundreds of types now.Gemini quaternary ammonium salt sterilizer is a kind of new sterilization agent,which has good biodegradability and strong sterilization effect,and the toxicity to human body is smaller than other quaternary ammonium salt sterilizing agent.Gemini quaternary ammonium salt is composed of two monomeric QAS molecules connected by a spacer,usually composed of hydrophobic groups,hydrophilic groups and spacer groups.The hydrophobic groups consist of hydrocarbon chains at both ends of the structure.The hydrophilic groups consist of two quaternary ammonium salts,and the spacer mainly serves to connect two hydrophilic groups.Gemini quaternary ammonium salt bactericide has stronger bactericidal effect than single-chain quaternary ammonium salt,and can achieve rapid bactericidal effect at very low concentration,has low chain affinity,easy biodegradation,low toxicity and low stimulation,and is green type products.It can be used in the washing industry to prepare detergents,detergents,fabric detergents,hair dyes,fabric softener,etc.,without the need for special processes and equipment,it can also be used for industrial water cycle fungicides,which the concentration of gemini quaternary ammonium salt can be reduced by an order of magnitude than that of single-quaternary ammonium salt and also be used for industrial,civilian sterilization,replace the traditional benzalkonium bromide and other quaternary ammonium salts sterilizers.Decamethoxin belongs to Gemini quaternary ammonium disinfectant in this topic and possesses all the merits of gemini quaternary ammonium disinfectant,and few domestic industrial production of decamethoxin.Therefore,Decamethoxin's industrial production research has a great effect on the development of enterprises.In this paper,two synthetic routes were designed by using the method of reverse synthesis.According to the actual operation,chemical reagents,reaction conditions and yield,the advantages and disadvantages of the two routes were evaluated and the final synthesis route of decamethoxin was determined.Decamethoxin was synthesized according to the determined route,and the final product was analyzed for quality.The Second Part:Alzheimer's disease(AD)is a neurological degenerative disease that slow onset and slow course of disease,AD is the fourth largest cause of death in the human,following heart disease,stroke,cancer.The pathogenesis of AD is complex,and the cholinergic hypothesis of Alzheimer's disease is recognized as a classical pathogenesis.This hypothesis suggests that the loss of cholinergic activity is related to the severity of AD.Studies have shown that acetylcholinesterase and butyrylcholinesterase can quickly break down choline in the body,the formation of inactive acid and choline,reduce the concentration of choline levels,thereby terminating nerve impulses.Acetylcholinesterase and butyrylcholinesterase all have a narrow capsule structure,mainly composed of peripheral site(PAS)and catalytic sites(CAS),CAS mainly to complete the hydrolysis of choline,and PAS can stabilize the binding of ligand to ChE,and enhance the binding strength of ligand to ChE.The purpose of this study is to investigate the effect of a drug on the peripheral locus(PAS)and catalytic site(CAS)of cholinesterase,to increase the inhibitory activity of drug molecules on cholinesterase,to find more effective cholinesterase enzyme inhibitors.The activity of eleven compounds was studied,the results showed that compound T-9 had the highest inhibitory activity on cholinesterase,and it could decrease the activity of T-9 on the basis of prolonging and shortening the length of the linker,tacrine ring 6-substituted chlorine or connecting medium introducing hetero atoms will cause the decrease of the activity of compounds.In this paper,the design of tacrine derivatives provides a certain way of thinking at the molecular level for the design of multi-site tacrine derivative.