| Objective: To investigate the effect of reinforcing kidney and spleen on Stage3 Chronic Kidney Disease(CKD)patients with spleen-kidney qi deficiency complicated by abnormal lipid metabolism and renal function.Methods: A total of 60 standard Stage 3 CKD patients with spleen-kidney qi deficiency,who were treated or hospitalized from October 2014 to October2016 in Department of Nephrology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,were selected.The selected patients were randomly divided into a control group and a treatment group at the ratio of 1:1.The control group received conventional basal therapy,and patients in the treatment group were given the treatment of reinforcing kidney and spleen besides conventional basal therapy.During three months of treatment,symptoms scores and clinical efficacies of the two groups were observed.The index changes of e GFR,Scr,Upro/Ucr,Bun,Cys-c and total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A(Apo A)and apolipoprotein B(Apo B)were detected.Results:By 12 weeks of clinical observation,the data display:(1)TC index: The treatment group showed that the average TC index changed to 5.02±0.63mmol/L after treatment.For the control group,the average TC index changed to 5.68±1.02mmol/L after treatment.The TC indexof the treatment group was lower than that of the control group,which is a statistically significant difference(P﹤0.05).(2)TG index: The average TG index of the treatment group changed to1.64±0.32mmol/L after treatment.For the control group,the average TG index decreased to 2.10±0.67mmol/L.Comparing the final TG indices after treatment,we can find that the efficacy of the treatment group was better than the control group.(3)HDL-C index: After treatment,the average HDL-C index for the treatment group decreased to 1.37±0.26mmol/L.For the control group,the same index only changed to 1.01±0.16mmol/L.Comparison of the two groups showed a statistically significant difference(P﹤0.05)..(4)LDL-C index: After treatment,the average LDL-C index of the treatment group changed to 2.04±1.01mmol/L.But for the control group,the average LDL-C index only decreased from 3.57±0.73 to 2.86±1.13mmol/L.Comparison of the two groups showed a statistically significant difference(P﹤0.05).Therefore,the treatment group was superior to the control group in improving LDL-C index.(5)For both groups,the changes of Apo A and Apo B indices before and after treatment were not statistically significant(P> 0.05).(6)Lipid-regulating efficacy: Comparing the lipid-regulating efficacy of the two groups,we found that,the total effective rate of the treatment group reached up to 96.67%,whereas the case for the control group was only80.00%.The difference was statistically significant(P <0.05).Therefore,the treatment group was obviously superior to the control group.(7)EGFR was significantly increased after the treatment group,Upro/Ucr significantly decreased,had statistical significance(P<0.05);Control group before and after treatment of e GFR,the Up-ro/Ucr changes without statistical significance(P>0.05);Treatment group Cys-c decreased significantly after treatment,was statistically significant(P< 0.05);The control group before and after treatment of Cys-c without significantly decreased(P>0.05);Compared with control group,treatment group after treatment Cys-c drop was statistically significant(P <0.05);Treatment group before and after treatment of Bun,Scr and contrast treatment group were no significant decline,comparing differences between the two way has no statistical significance(P> 0.05).(8)Symptoms scores: In terms of symptoms scores,the total effective rate of the treatment group reached up to 96.67%,but the total effective rate of the control group was only 73.33%.The difference was statistically significant(P<0.05).Therefore,the treatment group was significantly superior to the control group.Clinical efficacies: Comparison of the treatment group and control group in clinical efficacies after treatment showed a statistically significant difference(P﹤0.05).Conclusions(1)The reinforcing kidney and spleen treatment has obvious efficacies for Stage 3 CKD patients with spleen-kidney qi deficiency in terms of improving TC,TG,HDL-C and LDL-C indices,and can help to improve the clinical status of Stage 3 CKD patients complicated by abnormal lipid metabolism.(2)The reinforcing kidney and spleen treatment can improve the main clinical symptoms and quality of life for Stage 3 CKD patients withspleen-kidney qi deficiency.The total effective rate of the treatment group was significantly higher than the control group. |
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