Study On The Effect Of The Method Of Reinforcing The Kidney And Spleen On Improving The Chronic Low-grade Inflammation Of PCOS And Its Correlation With Obesity

Objective:To observe the effect of the method of tonifying the kidney and strengthening the spleen on improving the chronic low-grade inflammation of polycystic ovary syndrome(PCOS)with deficiency of the spleen and kidney,and to explore whether it is related to obesity.It provides ideas and references for the clinical application of the method of tonifying the kidney and strengthening the spleen to improve low-grade inflammation in the treatment of PCOS.Methods:57 patients with PCOS with spleen-kidney deficiency type were divided into obese group and non-obese group according to body mass index.Among them,28 cases were obese group and 29 cases were non-obese group.All were given Bushen Jianpi Decoction in order of addition and subtraction.The treatment is carried out for a total of 3 menstrual cycles.By monitoring the TCM syndrome scores of patients before and after treatment,serum inflammatory factors:C-reactive protein(CRP),interleukin-6(IL-6)and luteinizing hormone(LH),luteinizing hormone/follicle stimulating hormone(LH/FSH),testosterone(T),anti-Mullerian hormone(AMH)level changes,to evaluate the efficacy of the method of invigorating the kidney and spleen to improve the chronic low-grade inflammation of PCOS with spleen-kidney deficiency and its correlation with obesity.Result:(1)Before treatment,the age,course of disease,and TCM syndrome scores of the two groups of patients were statistically analyzed,and there was no significant statistical difference(P>0.05),which was comparable;(2)TCM syndrome score:Comparing the two groups before and after treatment,the TCM syndrome score was lower than before treatment,and there was a significant difference(P<0.05).There was no significant difference between the groups(P>0.05),indicating that sequential treatment of invigorating the kidney and strengthening the spleen It can effectively improve the symptoms and signs of TCM in patients with PCOS;(3)Sex hormones and AMH:Before and after treatment,LH,LH/FSH,T and AMH were all lower than before treatment,and there was a significant difference(P<0.05).There was no significant difference between the groups(P>0.05),indicating that the kidney is nourishing.Sequential therapy for strengthening the spleen can effectively improve the level of sex hormones and AMH in patients with PCOS;there is no statistically significant difference between the LH,LH/FSH,T and AMH groups before and after treatment(P>0.05).Therefore,it cannot be explained that the kidney and the spleen are invigorated Recipe sequential treatment to improve the efficacy of LH,LH/FSH,T and AMH in PCOS patients is related to obesity;(4)Inflammatory factors:①Before treatment,the obesity group had higher CRP and IL-6 levels than the non-obese group,and the difference was statistically significant(P<0.05),indicating that the degree of inflammatory damage in obese patients was more serious than that in non-obese patients;②After treatment,the CRP and IL-6 of the two groups decreased,and the difference was statistically significant(P<0.05),indicating that the sequential treatment of Bushen Jianpi Decoction can effectively improve the chronic low-grade inflammation in patients with PCOS;③Comparison of differences between groups before and after treatment,Both groups were statistically significant(P<0.05),linear regression suggested that there was no correlation between grouping and CRP and IL-6 after treatment(P>0.05).Combined with the conclusions ①②,it shows that the sequential treatment of Bushen Jianpi Decoction can reduce obesity CRP and IL-6 levels in PCOS patients have more significant curative effects;(5)Safety observation:No obvious adverse reactions were found in the two groups of patients during the treatment period,and the safety was good.Conclusion:Treatment with Bushen Jianpi Decoction can effectively improve the TCM syndromes and signs of PCOS patients,can effectively relieve the clinical symptoms of spleen and kidney deficiency,improve the patients’ menstrual status,the level of sex hormones and AMH in the body,reduce the level of pro-inflammatory factors,and improve chronic low-grade inflammation in patients.The inflammatory state in obese PCOS patients is more obvious,and the sequential treatment of Bushen Jianpi Decoction is more effective in improving chronic low-grade inflammation in obese PCOS patients.