| Cbjective:Observation of ?/? NSCLS patients with malignant pleural effusion in pleural effusion for malignant pleural effusion underwent treatment of two different treatment mode remission rate,KPS score,improve the function of thoracic tumor marker positive water content changes with the treatment of pure Chi nese medicine or traditional Chinese medidicine and Western Medicine(overall),observe the overall survival of survival,and OS)the medi an survival time(median survival,time,MST)affect the long-termefficacy of the treatment effect of traditional Chi nese medi cine mainly in advanced lung cancer with malignant pleural effusion.Method:A retrospective analysis of January 1,2014 January 1,2017 in the Hubei Provincial Traditional Chi nese Medical Hospital oncology clinical research(the Garden Hill School District and the D strict of Optics Valley)during hospitalizati on in patients with advanced(?,?)non-small cell lung cancer(NSCLS)in 43 cases with malignant pleural effusion treated with combines traditional Chinese and Vestern medicine treatment of patients,divided into traditional Chi nese and Western medicine group(20 cases)and treatment group(23 cases),all patients under the gui dance of ultrasound in localization,drai nage of thoracic puncture,puncture and drai nage of the first day to send pleural effusion specimen containing pleural effusion,pleural effusion,conventional bi ochemical pleural fluid cytology and tumor markers(CEA,AFP,a full set of CA125 CA153,and CA199),as far as possible(Note:thoracic drainage water drai nage can not every day more than 1500mL),to be combined with pleural perfusion chermotherapy drug treatment group or injection of Chinese medicine combined with chemotherapy medicine of traditional Chinese Medicine and Western medicine,next time,The treatment regimen of combination of TCMand Western medicine by 1-2 injection of Chinese medicine and(or)oral herbal medicine;Chinese medicine treatment group only after thoracic puncture drainage without pleural perfusion,conservative treatment was given TCMtreatment group therapy:Traditional Chinese medicine herbal medicine + drug injection.During the treatment the patients were treated with traditional Chinese medicine to consolidate the treatment,continuous observation of two weeks,the positive part of the review of pleural fluid in patients with ultrasound and tumor marker to observe the curative effect of two groups of patients(pleural effusion rate,KPS score,improve the function of thoracic tumor marker Water content),and then continue to follow up all patients the track,thelength of survival and overall survival Were followed up after(overall survival,OS)and the median survival time(median survival,time,MST)analysis,calculation of OS and MST by Kaplan.Meier method.Results:?Comparison of the two groups of pleural effusion remission rate:20 cases of Chinese and Western medicine combined treatment group,CR 16 cases,PR 3 cases,SD1 case,PD 0 cases,total remission rate(total rermission rate = CR + PR)was 82.60%,Chinese medicine group,CR(7 cases),PR(6 cases),SD(8 cases),PD(2cases),total remission rate(CR + PR)was 56.6%,and there was significant difference between the two groups P<0.05).? The distribution of KPS score before treatment in two groups was basi cally normal distribution,and the independent samplet test was used to compare the two groups.T = 0.73<t0.05,then P>0.05,There was no significant difference in the KPS score between the two groups before treatment.After treatment,the difference between the two groups was improved in the KPS function score.The difference between the two groups was X2 = 7.46>X20.05.2,P<0.05,Improve the KPS function score on the difference,a statistically significant.(P<0.05).? Description of all pleural effusion of patients with tumor markers CEA,CA125,CA199,AFP,CA153 statistics,the positive tumor markers(CEA,CA125,CA199)by using CCX multi factor retrospective analysis,analysis of the content of the combined effect of tumor marker in patients with malignant pleural effusion and the prognosis of survival for advanced NSCLC,especi ally the contents of CEA,CA125 and the dueation of survival,so we use CEA and CA125 as the impact of adverse factors,prognosis of malignant pleural effusion P<0.05,the difference was statistically significant;? The median CS was 18 months in the 43 patients who were foll owed up for 16 months.The median OS was 18 months in the sequential Chinese medicine group and 13 months compared with the simple Chinese medicine treat ment group.The resulis of stratified anal ysis showed that the sequential sequential and perfusi on treatment of traditional Chinese medicine could prolong the survival time of patients with advanced lung cancer with malignant pleural effusion(P<0.05).Compared with the patients with advanced adenocarci noma with malignant pleural effusion(P<0.05).Ade nocarcinornais one of the poor prognosis of advanced lung cancer with mali gnant pleural effusion.The prognosis of patients with advanced lung cancer and advanced type of lung cancer with malignant pleural effusion is poor and the survival time is statistically significant(P<0.05).Conclusion:Chinese medicine and Western medicine treatment compared to cooperate simplemedical treatment can prolong the median survival time than simply Integrative Medicine Chinese medicine adjuvant therapy of malignant pleural effusion advantage,not only can improve efficacy,prolong survival,and may reduce chemoherapy side effects of drugs,which highlights the role of traditional Chinese medicine in the treatment of mailignant pleural effusion secondary palliative. |
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