Hemorheological Changes And Clinical Significance In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To study the hemorheological changes and clinical significance in patients with obstructive sleep apnea hypopnea syndrome.Methods:Polysomnography(PSG)and hemorheology were performed in 40 OSAHS patients and 20 healthy volunteers.The indexes of hemorheology include hematocrit,whole blood viscosity(high shear rate,medium shear rate,low shear rate),erythrocyte aggregation index,plasam viscosity and fibrinogen concentration.Polysomnography indicators include:body mass index(BMI),apnea hypopnea index(AHI),the lowest oxygen saturation(LSaO2),and the spent time Percentage of oxygen saturation<90%accounted for the total sleep time(STPSaO2<90%).According to the results of AHI,the OSAHS group was divided into mild group(15 cases),moderate group(n = 12)and severe group(n = 13).To compare the difference of hemorheology between groups.Results:1.Control group compared with mild OSAHS group,the moderate group compared with the severe OSAHS group,the indexes of hemorheology there was no significant difference.Compared with the mild OSAHS group,the whole blood viscosity,HCT and erythrocyte aggregation index of moderate and severe OSAHS group has significant difference(P<0.05);and plasma viscosity and fibrinogen concentration without statistical difference.2.Compared with the control group,BMI in severe OSAHS group has signifi-cant difference(P<0.01);Compared with the control group,the levels of LSaO2,and MSaO2 in the moderate OSAHS group has significant difference(P<0.05),STP-SaO2<90%in the moderate OSAHS group has significant differencet(P<0.01).Co-mpared with mild OSAHS group,the levels of LSaO2,MSaO2 andSTPSaO2<90%in severe OSAHS group has significant difference(P<0.01).3.Blood viscosity,erythrocyte aggregation index and HCT were positively correlated with AHI and STPSaO2<90%,but negatively correlated with LSaO2 and MSaO2(P<0.05),but no correlation with BMI.Conclusion:1.OSAHS patients with abnormal hemorheology,and with the aggravation of the disease,blood rheology index has an increasing trend.2.The abnormality of Hemorheology in patients.with OSAHS was related to sleep disorder,sleep apnea,and decreased blood oxygen saturation.