Factors Influencing EEG At The Onset Of 125 Patients With Viral Encephalitis And Its Relationship With Prognosis

Objective:To analyze the clinical and electroencephalogram(EEG)characteristics of 125 cases of viral encephalitis,and to explore the influencing factors of EEG and its relationship with prognosis.Methods:1.A retrospective analysis was used to collect patients with viral encephalitis who were admitted to the Department of Neurology and EEG room at the First Affiliated Hospital of Dalian Medical University from January 1,2012 to November 15,2016.125 cases.Record the clinical and EEG data of patients:sex,age.onset season,EEG.head imaging examination,cerebrospinal fluid(pressure,white blood cell count,protein quantification),the first symptom,clinical symptoms,short-term prognosis and other items.All patient data were summarized and the database was established.2.The descriptive analysis of the general data of 125 patients with viral encephalitis was carried out.The correlation between EEG abnormalities and prognosis was analyzed.The factors influencing the EEG were analyzed by univariate and multivariate analysis.The correlation between influencing factors and prognosis of EEG in the early stage of disease was analyzed.3.Metrological data were expressed as mean ± standard deviation(x ± s),positive data using independent sample t test,non-normal data using Mann-Whitney U rank test.Counting data between groups were compared using χ2 test.Multivariate analysis using binary logistics regression analysis.P<0.05 was statistically significant.Results:There were 125 patients with viral encephalitis,including 78 males(62.4%)and 47 females(37.6%);the age quartile was 43(26.60),the youngest was 14 years old,Among them,66(52.8%)were middle-aged.27 were middle-aged(21.6%),24 were old(19.2%),8 were old(6.4%),and 0 were old(0%);(28.8%),36 cases(28.8%),26 cases(20.8%)and 27 cases(21.6%),respectively.At the beginning of the initial imaging findings:positive in 25 cases(20.0%),negative in 100 cases(80.0%).100 cases of viral encephalitis in patients with early onset of EEG results showed:normal 13 cases(13.0%),5 cases(5.0%),mild abnormalities in 17 cases(17.0%),moderate abnormalities in 49 cases(49.0%).Severe abnormalities in 16 cases(16.0%).109 cases of viral encephalitis in patients with cerebrospinal fluid at the onset of cerebrospinal fluid showed normal cerebrospinal fluid pressure in 89 cases(81.7%),increased in 20 cases(18.3%),decreased 0 cases(0%);cerebrospinal fluid in normal white blood cells in 49 cases(45.0%(17.2%),moderate increase in 19 cases(17.4%),severe increase in 19 cases(17.4%);normal cerebrospinal fluid protein in 69 cases(63.3%),increased in 35 cases(32.1%),down 5 cases(4.6%).The distribution of the first symptom in 125 patients with viral encephalitis showed fever in 42 cases(33.6%),31 cases of headache(24.8%),epilepsy in 19 cases(15.2%),mental disorders in 17 cases(13.6%),disturbance of consciousness 8(6.4%),dizziness,nausea and vomiting in 5 cases(4.0%),hemiplegia in 1 case(0.8%),2 cases of herpes(1.6%).The number of cases of morbidity,psychosis,epilepsy,disturbance of consciousness and hemiplegia were 104 cases(83.2%),68 cases(54.4%),48 cases(38.1%).41 cases(32.5%),1 case(0.8%).Short-term prognosis showed complete recovery of 35 cases(28.2%),mild to moderate sequelae in 72 cases(58.1%),severe sequelae in 13 cases(10.5%),death in 4 cases(3.2%);good prognosis in 107 cases(86.3%,Poor prognosis in 17 cases(13.7%).2.Univariate analysis of influencing factors of EEG at the onset of EEG showed that the number of white blood cells in cerebrospinal fluid was increased,the onset of headache and epileptic seizures,psychiatric symptoms,epilepsy and disturbance of consciousness and EEG abnormalities The difference was statistically significant(P<0.05).Multivariate analysis showed that epilepsy in clinical symptoms was associated with abnormal EEG at the onset of EEG,and the difference was statistically significant(P<0.05).3.The results of EEG and short-term prognosis showed that the severity of EEG at the beginning of the disease was related to the short-term prognosis,the difference was statistically significant(P<0.05).4.The results of epilepsy and short-term prognosis were statistically significant(P<0.05).Conclusions:1.Epilepsy is the risk factor of EEG abnormalities at the onset of viral encephalitis.2.Recent prognosis is related to the abnormal degree of EEG at the onset of disease.3.Patients with viral encephalitis with epilepsy as the main clinical symptoms have poor recent prognosis.