Correlative Factors Analysis Of Mild Obstructive Sleep Apnea Hypopnea Syndrome Patients Accompany With Cognitive Dysfunction

Objectives:Obstructive sleep apnea hypopnea syndrome(OSAHS)is apt to lead to cognitive dysfunction,but the exact mechanisms remain unclear.This research is aimed at observing white matter structural changes by magnetic resonance Diffusion Tensor Imaging(DTI)and detecting high sensitivity C-reactive protein(hsCRP),apnea hypopnea index(AHI),lowest oxygen saturation(LSa02),mean oxygen saturation(MSa02)as well as analysising the relationship between cognitive decline and abnormal white matter structural changes,hsCRP,AHI,LSa02,MSaO2 in mild OSAHS cognitive dysfunction patients.To explore the he possible pathogenesis of OSAHS cognitive dysfunction and provide the basis of early intervention for early stage of mild OSAHS cognitive dysfunction patients.Research Design and Methods:Polysomograph was performed in 12 patients(5 male and 7female)with mild OSAHS cognitive dysfunction and in 12(6male and 6female)sex-and age-matched snoring non cognitive dysfunction patients.We obtained two groups of patients' hypoxia parameters(AHI,LSaO2,MSaO2)data by PSG test.The levels of hsCRP in fasting serum of two groups were detected.All the patients were examined by DTI,and based on the Region of Interest(ROI)we observed plot of the white matter area's fractional anisotropy(FA)and measured the FA values.The correlation between MoCA,MMSE score and mean FA,hsCRP,PSG and ESS score was analyzed.The data were analyzed by SPSS 20.0 software.Results:1.Compared to the control group,MoCA score decreased(25.3± 1.42 vs 27± 1.33,p=0.013),AHI increased(7.44±2.28 vs 1.99±1.63,P=0.000),hsCRP increase(1.96± 1.72)vs 0.61 ±0.90,P=0.041)in OSAHS group,the difference was all statistically significant.2.Compared to the control group,the left cerebral peduncle(0.721 ±0.09 vs 0.824±0.046,P=0.009),right posterior cingulate(0.25±0.14 vs 0.43±0.024,P=0.045),left posterior limb of the internal capsule(0.56±0.24 vs 0.75±0.04,P=0.016),right posterior limb of the internal capsule(0.57±0.21 vs 0.72±0.05,P=0.028),left parahippocampal gyrus(0.25±0.11 vs 0.35±0.06,P=0.033)FA score decreased,the difference was statistically significant.3.Spearsman correlation analysis show:MoCA score has negative correlation with AHI(r =-0.708,P?0.022),MoCA score has no negative correlation with age?BMI?hypertension?diabetes?smoking?drink?mean FA value?LSa02?MSa02(P>0.05)?4.A significant negative correlation was observed between MoCA score and AHI(r=-0.708,P=0.022),and the linear regression analysis indicated that MoCA score and AHI(B=-0.440,T=-2.838,P=0.022),as AHI increase each 1/min,MoCA score decreased 0.44 points.Conclusions:(1)These results suggest that mild OSAHS patients have mild cognitive dysf-unction.Inflammatory response may play a role in pathogenesis of mild OSAHS mild cognitive dysfunction.AHI is independent risk factors for mild OSAHS mild cognitive dysfunction patients.AHI increase each 1/min,MoCA score decreased 0.44 points.(2)White matter structure changes occur in mild OSAHS mild cognitive dysfunction patients,mainly distributed in the left posterior cerebral peduncle,the right posterior cingulate,bilateral internal capsule,left parahippocampal gyrus.