The Effectiveness And Rationality Analysis Of Anti-tuberculosis For Pericardial Effusion Patients Without Tuberculosis Evidence

Tuberculous pericarditis is a chronic progressive disease infected by mycobacterium tuberculosis,the clinical manifestations are not specific,and pericardial effusion culture and pericardial tissue biopsy are the gold standard,the lack of rapid diagnosis is still a clinical problem.Tuberculous pericarditis is often delayed or even misdiagnosed in clinical work.Exclude neoplastic,rheumatic and other etiologies,patients with suspected tuberculous pericarditis can receive anti-tuberculosis treatment.But patients with non-tuberculosis evidence,the necessity,effectiveness and safety of the diagnostic anti-tuberculosis treatment are not clear.Exclude neoplastic,rheumatic,non-tuberculous infection,highly suspected tuberculosis infection and other etiologies,this study was retrospectively analyzed clinical data about large pericardial effusion patients with non-tuberculosis evidence and unknown etiologyies,then confirm the standard and assess the effectiveness and safety of the diagnostic anti-tuberculosis treatment.Objective:Exclude neoplastic,rheumatic,non-tuberculous infection and other etiologies,to analyze the effectiveness of diagnostic anti-tuberculosis treatment for large pericardial effusion patients with non-tuberculosis evidence.Methods:Retrospective analyze pericardial effusion patients with unknown etiologies from January 2013 to September 2016 of Peking Union Medical College Hospital.Excluded neoplastic,rheumatic,nontuberculous infection disease,then choose patients with non-tuberculosis evidence and received diagnostic anti-tuberculosis treatment as study group;another group of patients with clear or highly suspected tuberculous evidence and received anti-tuberculosis treatment as control group.Statistical analysis of the patients’ symptom relief,pericardial effusion relief and clinical outcomes between study group and control group to assess the effectiveness and rationality of diagnostic anti-tuberculosis treatment in pericardial effusion patients with non-tuberculosis evidence.Results:57 patients with pericardial effusion were divided into study group(n = 25)and control group(n = 32)according to the include and exclude criteria.Two groups of patients were regular anti-tuberculosis treatment,and the statistical analysis of anti-tuberculosis treatment,clinical symptoms relief,pericardial effusion relief and clinical outcomes were no significant difference(P>0.05).Conclusions:Pericardial effusion patients that already exclude neoplastic,rheumatic immunologic and infective diseases,with no tuberculosis evidence can receive anti-tuberculosis treatment.