Lymphocyte-to-monocyte Ratio And Prognosis Of Breast Cancer

Objective: This article on the relationship between preoperative and postoperative LMR pathology and clinical prognostic factors in patients with breast cancer study.To investigate the prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with breast cancer who received radical resection.Methods: A restropective review was performed on 92 patients who underwent radical resection for breast cancer in our hospital between January 2006 and December 2010,all patients were diagnosed with breast cancer by pathological examination.Record lymphocyte cell,monocyte cell and postoperative pathological data were statistically analyzed.Results: 1.The best cut-off value of LMR(=5.83)at preoperative was identified according to the receiver operating characteristic curve(ROC curve),all the patients were divided into two groups: a high LMR(≥5.83,n=49)group and a low LMR(<5.83,n=43)group.2.There was no statistically significant difference in the clinicopathological characteristics between preoperative LMR(P<0.05,for all).3.The 5-year overall survival rate was 89.4% in patients of the high LMR group and 76.7% in those of the low LMR group(P<0.001).4.Univariate analysis showed TNM stage,estrogen receptor,progesterone receptor and LMR were associated with survival(P<0.05,for all).Kaplan Meier survival curve shows that DFS of high LMR group is greater than lower DFS group wite breast cancer patients significantly longer.5.Multivariate analysis revealed that TNM stage,estrogen receptor,progesterone receptor,Ki-67,human epidermal growth factor receptor-2 and LMR were independent prognostic factors(P<0.05,for all).Conclusion: 1.Preoperative LMR=5.83 can be used as the critical value in predicting the prognosis of breast cancer patients.2.Preoperative LMR≥5.83 is an independent factor to predict the prognosis of patients with breast cancer.3.Preoperative LMR may serve as a marker of prognosis for breast cancer patients.