| Objective:Observe the Modified Danggui Shaoyao Powder combined Freeze-dried Xueshuantong for injection-lontophoresis effects on Phlegm-blood stasis mutual junction age-related macular degeneration,fundus morphology and visual function.Methods:a total of 50 patients with phlegm-blood stasis syndrome type AMD(73 eyes),26 cases(38 eyes)of men,24 cases(35 eyes)of women,according to the medical order,were randomly divided into two groups:control group in 25 cases(35eyes),treatment group25 cases(38eyes).Control shall be oral Chinese medicine granule the Modified Danggui Shaoyao Powder,the treatment group on the basis of the control drug to Freeze-dried Xueshuantong for injection-lontophoresis.Respectively observed two groups of patients before treatment and 4 weeks after treatment the best central vision correction,the cubic average thickness in the macular area and the thickness of macular area center area in OCT,the mean defection and the pattern standard deviation in Perimetry.Results:1.The acuity of the treatment group was 0.31±0.23,and 0.49±0.30 for 4 weeks,and the difference was statistically significant(P =0.000<0.05).In the control group,the visual acuity was 0.30±0.21,and 0.3410.23 for 4 weeks.The difference was statistically significant(P=0.022<0.05).There was no statistical difference between the treatment group and the control group of the control group(P=0.840>0.05),and the correlation was statistically significant(P=0.019<0.05).2.The average thickness of the treatment group was 312.08±65.40,and the following four weeks were 261.29 ±41.38,the difference wasstatistically significant(P=0.000<0.05;The control group was 296.89±61.42,and the following four weeks were 285.17±48.90,and the difference was statistically significant(P=0.003<0.05);Treatment group and control group before treatment macular ILM-average thickness contrast RPE cube no statistical difference(P=0.311>0.05),4 weeks after treatment compared with statistical difference(P=0.027<0.05).The treatment group yellow spot ilm-rpe center was 303.74 ± 425,and the following four weeks were 257.13±30.09,the difference was statistically significant(P=0.000<0.05).The control group was 292.74±35.72,and the following four weeks were 272.63 ± 33.16,and the difference was statistically significant(P=0.002<0.05);Treatment group and control group before treatment macular thickness of ILM-RPE center area contrast has no statistical significance(P=0.249>0.05),4 weeks after treatment compared with statistical difference(P=0.040<0.05).3.The treatment group had an absolute value of 8.32±6.45,and 4.87±3.29 for four weeks,and the difference was statistically significant(P=0.000<0.05).The control treatment was 8.53±6.72,and the following 4 weeks was 6.85±4.03,and the difference was statistically significant(P=0.000>0.05).The absolute absolute value of the treatment group and control group was statistically significant(P=0.821>0.05),and the correlation was statistically significant(P=0.024<0.05).The standard deviation of the treatment group was 5.09±2.47,and the following four weeks were 3.74±1.54,and the difference was statistically significant(P=0.000<0.05).The control group was 5.48±2.78 before treatment,4.94±2.39 for 4 weeks,and the difference was statistically significant(P=0.001<0.05).4.The comparison of the standard deviation of the treatment group and the control group was statistically significant(P=0.520>0.05),and the correlation was statistically significant(P=0.012<0.05).The treatment group was evaluated for 4 weeks of vision,21 eyes,12 eyes and 5 eyes,total efficiency was 86.84%.Control group4 weeks after treatment eyesight curative effect evaluation,8 eyes had marked effect,14 effective eye,invalid 13 eyes,the total effective rate was 62.86%,statistically significant difference were observed in the treatment group and control group(P=0.018<0.05).Conclusion:1.Traditional Chinese medicine(TCM)flavored angelica extract powder of oral treatment of phlegm and blood stasis mutual junction AMD clinical curative effect affirmation.Can effectively improve the patients' central vision,vision and macular morphology changes.2.Chinese medicine oral joint flavored angelica extract powder thrombosis through iontophoresis method in the treatment of phlegm and blood stasis mutual junction AMD clinical curative effect is distinct,in improving eyesight,improve patient's average visual defect and pattern standard deviation,improve the macular morphology,reduce the average thickness macular area cube center area and the thickness of the aspects such as obvious effect,and is superior to the pure oral flavored angelica extract powder.3.Chinese medicine oral joint flavored angelica extract powder blood clots pass iontophoresis treatment the curative effect of phlegm and blood stasis mutual junction AMD mechanism may be through anti-inflammatory,antioxidant,anti-aging,fall hematic fat,inhibit platelet aggregation,improve hemorrheology,promote the absorption of oedema and blood stasis,so as to protect the retina barrier,anti-aging,improve microcirculation,retinal resume the function of the retina.It remains to be further in-depth study. |
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