Clinical Analysis Of Cervical High Risk HPV Infection And Cervical Lesions In Postmenopausal Women

Background and objective:HPV infection is associated with the occurrence and development of a variety of cervical lesions,and it has been confirmed that the persistent infection of high-risk HPV is an important risk factor for the development of cervical cancer.Studies have shown that young sexually active women at high risk of HPV infection and cervical neoplasia,with age,the risk of significantly reduced,but the risk of cervical cancer increased by.To investigate the relationship between HPV infection and cervical lesions in postmenopausal women with high risk of HPV infection,to clarify the necessity of screening,and to improve the understanding of cervical infection and cervical lesions.Methods:A total of 1128 female patients with high risk of HPV infection and cervical biopsy were collected from the first hospital of Jilin University from January 2014 to October 2016.There were a total of 328 cases of menopausal women in.Using the retrospective method,comparative analysis of the clinical data of 1128 cases of infection in patients with cervical high-risk HPV virus,the grade data into rank-sum test and analysis of count data using chi-square test for statistics.Result:1,Among the 17248 patients admitted to No.1 Hospital of Jilin University from January 2014 to October 2016,1128 female patients with high-risk HPV infection were detected,of whom 328 were postmenopausal,accounting for about 29%,and 800 were not postmenopausal,accounting for about 71%.On the comparison to high-risk HPV infections among all age groups,found 20 to 60 years old age group is significantly higher than other age groups,and postmenopausal HPV infection were more concentrated in the 50 to 60 years old.2,Postmenopausal cervical high risk HPV infection in this group of women after a total of 328 cases were cervical biopsy,27 cases of chronic cervicitis or normal cervical tissue of patients with the pathological return,accounting for 8.23%(27/328);21 cases of LSIL patients,accounting for 6.40%(21/328);123 cases of HSIL patients,accounting for 37.5%(123/328);157 cases of patients with cervical cancer,accounting for 47.87%(157/328).3,Women’s menopause group TCT screening negative patients were 77 cases,including 21 cases of patients with chronic cervicitis or normal cervical tissue,accounts for only about 27.27%;10 patients with LSIL,accounting for 12.99%;32 patients with HSIL,accounting for 41.56%;2 patients with carcinoma in situ,accounting for 2.6%;12 patients with cervical cancer,accounting for 15.58%.4,This group of data of cervical high risk HPV infection in patients with a total of 1128 cases were cervical biopsy pathology,328 cases of postmenopausal group,group of 800 cases of not postmenopausal.Compared two groups of cervical biopsy pathology results,the differences are significant(P < 0.05),postmenopausal group the incidence of cervical cancer was 47.87%(157/328),higher than the 22.75% of menstruating group(182/800).Postmenopausal group of patients with cervical HISL proportion was 37.5%(123/328),not postmenopausal group was 55.13%(441/800);Postmenopausal group of patients with cervical LSIL proportion was 6.4%(21/328),not postmenopausal group was 3.5%(28/800);Group of chronic cervicitis menopause or proportion of normal cervical tissue was 8.23%(27/328),not postmenopausal group was 18.6%(149/800).5,There were 754 cases of cervical high risk HPV virus infection with cerical cytology(TCT)in the group of patients,including postmenopausal group 192 cases,not postmenopausal group 192 examples.The results of TCT examination of the two groups were significantly different(P < 0.05).Group TCT showed normal or inflammation in postmenopausal patients accounted for 40.10%(77/192),ASCUS accounting for 28.65%(55/192),LSIL accounted for 3.65%(7/192),HSIL accounted for 27.08%(52/192),SCC or adenocarcinoma accounted for 0.52%(1/192);the premenopausal group TCT showed normal or inflammation patients accounted for 41.99%(236/562),ASCUS accounted for 24.02%(135/562),LSIL accounted for 7.30%(41/562),HSIL accounting for 25.98%(146/562),SCC or adenocarcinoma accounted for 0.71%(4/562).6,A total of 772 patients with cervical high risk HPV infection complicated with cervical intraepithelial neoplasia or cervical cancer were examined by colposcopy in this group of patients,223 cases of postmenopausal group,group of 549 cases were not menopause.The results of colposcopy revealed that the white epithelium,mosaic,punctate vessels,abnormal blood vessels,lard like changes,changes in the pattern of vegetables and other images,established as an abnormal colposcopy.The detection rate of abnormal vaginal examination in the menopausal group was 81.2%,and that of the premenopausal group was 91.8%.Postmenopausal vaginal lens detection rate is lower than the menstruating group,two groups compare differences are significant(P < 0.05).7,A total of 593 cases of cervical high risk HPV infection with cervical intraepithelial neoplasia or cervical cancer were examined,166 cases of postmenopausal group,group of 427 cases of not postmenopausal.With ASCUS and above for abnormal cervical cytology,menopause group of cervical cytology detection rate is about 68.07%,not postmenopausal group was 75.18%.Menopause cytology detection rate is lower than not postmenopausal group,two groups compare differences are significant(P < 0.05).8,The cervical cytological examination of ASCUS and above,the pathological results suggest that CIN and above is consistent with positive cytology and pathology;cytological examination showed normal,pathological results of chronic cervicitis or normal cervical tissue with negative cytology and pathology.The coincidence rate of cytology and pathology in the menopausal group was 68.75%,and that of the non menopausal group was 80.25%.The difference between the two groups was significant(P<0.05).Conclution:1,The detection rate of abnormal cervical cytology,the abnormal rate of colposcopy and the coincidence rate of cytology and pathology in postmenopausal women with high-risk HPV infection were decreased.2,In order to prevent the occurrence of cervical cancer,it is necessary to pay attention to the screening and early diagnosis of cervical cancer.3,Postmenopausal women with high-risk cervical HPV infection should be highly regarded even if TCT or colposcopy are negative.