| Objective :Study on obstructive sleep apnea hypopnea syndrome(OSAHS)and partial thromboplastin time(APTT),prothrombin time(PT),platelet aggregation rate(PAG%),plasma fibrinogen(FIB),antithrombin III(ATIII%),D-dimer(D-D)correlation.Method:Such databases as Pub Med databases,the Chinese journal full text database,Cochrane library database,Chinese biomedical literature database,Wanfang database,and manual retrieval were included in the literature.Time set for January 1996 to September 2016,no language limit.English retrieval formula:(obstructive[All Fields] AND("sleep apnea,obstructive" [Me SH Terms] OR("sleep" [All Fields] AND "apnea" [All Fields] AND "obstructive" [All Fields])OR "obstructive sleep apnea" [All Fields] OR("sleep" [All Fields] AND "apnea" [All Fields] AND "hypopnea" [All Fields] AND "syndrome" [All Fields])OR "sleep apnea hypopnea syndrome" [All Fields])AND("blood coagulation" [Me SH Terms] OR("blood" [All Fields] AND "coagulation" [All Fields])OR "blood coagulation" [All Fields] OR "coagulation" [All Fields] OR "blood coagulation tests" [Me SH Terms] OR("blood" [All Fields] AND "coagulation" [All Fields] AND "tests" [All Fields])OR "blood coagulation tests" [All Fields]))OR(prethrombotic[All Fields] AND state[All Fields])。And select Newcastle-Ottawa Scale(NOS)system to assess the quality of the literature,Revman5.3 software provided by Cochrane collaboration network for Meta analysis.Results the weights and measures of the measurement units,the same continuous variables using weighted mean difference(WMD),the classification of variables using the mean weighted mean difference(MD),and 95% confidence intervals(CI).For the heterogeneity of the results of the study,I2=50% was used as the standard.When I2>50%,the research results are statistical heterogeneity,need to find out the sources of heterogeneity,and the random effects model(random effects model,REM);when I2<50%,the results are no statistical heterogeneity,then use the fixed effects model(fixed effects model,FEM).And P<0.05 was statistically significant.And 2 reviewers independently completed the literature screening,data extraction and cross check,if there are differences,refer to the views of the third party.Results:1.A total of 13 case-control studies were included,including a total of 1256 cases.The NOS system was used to evaluate the quality of the 13 articles included in the study,and the results of the evaluation were higher than those of the literatures.2.Meta analysis results showed that:(1).OSAHS group and control group APTT results showed that the difference between the two groups was statistically significant(-6.52.-1.63,[MD=-4.07,95%CI)P=0.001],suggesting that OSAHS group of patients with APTT was significantly shorter than the control group;(2).OSAHS between PT group and control group showed that there was significant difference between two groups [MD=-1.87,95%CI(-2.51-1.04),P<0.00001],suggesting that OSAHS group PT was significantly shorter than the control group;(3).OSAHS between FIB group and control group showed that: the difference between the two groups was statistically significant [MD=0.84,95%CI(0.44,1.05),P<0.00001],suggesting that OSAHS group FIB was significantly longer than the control group;(4).OSAHS group and control group PAG% the comparison results show that the difference between the two groups was statistically significant([MD=7.14,95%CI 0.30,13.98),P=0.04],suggesting that OSAHS group PAG% was significantly higher than the control group;(5)D-D group,.OSAHS group and control The results showed that [MD=0.21 was statistically significant difference between the two groups,95% CI(0.17,0.25),P<0.0 0001],D-D OSAHS group was significantly higher than the control group;(6).OSAHS AT-III% group compared with the control group showed that there was significant difference between two groups [MD=-22.11,95%CI(-29.71,-14.52),P<0.00001],suggesting that group OSAHS AT-III% was significantly shorter than the control group.Conclusion:1.Obstructive sleep apnea syndrome is closely related to coagulation fibrinolysis system,which has high blood coagulation state and is easy to form pathological thrombus.2.The detection of blood related indexes can be used to evaluate the severity of the disease. |
