Clinical Study Of Prethrombotic Status In Patients With Different Degree Obstructive Sleep Apnea Syndrome

Objective:By analyzing the indicators of prethrombotic state to explore the changes of prethrombotic status and its clinical significance in the different degree of OSAS patients,to provide the theory basis for prevention of thromboembolic disease.Methods:The study subjects were hospitalized patients in yan ’an hospital affiliated to kunming medical university from January,2016 to March,2018.Among them,70 patients of OSAS in the experimental group were divided into mild 23 cases,moderate 22 cases and severe 25 cases according to PSG monitoring results.In the control group,20 patients were diagnosed with simple snoring after PSG examination(AHI<5).The relevant laboratory indexes of the two groups were collected during hospitalization,including the indexes of routine coagulation(prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT));platelet related indexes(mean platelet volume(MPV)and platelet distribution width(PDW));the indexes of rheology(hematocrit(HCT));fibrinolytic-resistant fibrinolytic compounds markers(fibrinogen(FIB),D dimer(D-D),fibrin degradation products(FDP)(original)),and the above indexes between the experimental group and control group,different degree between the experimental group for statistical analysis.Collected at the same time the experimental group patients with polysomnography related indicators,including apnea hypopnea index(AHI),mean oxygen saturation(MSa02),the lowest oxygen saturation(LSa02),and the above indicators were correlated with the PTS index.Results:1.Compared with the control group,the patients in the experimental group of OSAS showed decreased PT and APTT,while FIB,DD,FDP,MPV and PDW increased.Patients with mild OSAS had higher MPV and PDW than patients with simple snoring.Patients with moderate OSAS had DD only increased compared to those with mild patients.The patients with severe OSAS were lower than those with mild patients PT and APTT,while FIB,d-d,FDP and HCT were all increased.In patients with moderate OSAS,DD,MPV and PDW were all increased compared with those of patients with simple snoring.The patients with severe OSAS were lower than those with moderate patients PT,APTT and TT,while FIB and FDP increased.The patients with severe OSAS were lower than patients with simple snoring PT and APTT,while FIB,DD,FDP,HCT,MPV and PDW were all increased.2.In the experimental group,PT and APTT were negatively correlated with AHI,while FIB,DD,FDP were positively correlated with AHI.PT and APTT were positively correlated with MSa02;PT and APTT were positively correlated with LSa02,while FIB,DD and LSa02 were negatively correlated.The correlation,analysis of the other indexes showed no significant correlation.Conclusion:Patients with OSAS had prethrombotic status,and patients with severe OSAS were more obvious,with a greater risk of severe thrombotic disease.Prethrombotic state related indicators(PT,APTT,FIB,DD,FDP,HCT,MPV,PDW)may serve as an important reference for assessing the risk of thrombotic disease in patients with OSAS.