| Objective:Through the method of evidence-based medical system evaluation and meta-analysis,the therapeutic effect and safety of acupuncture in the treatment of chronic fatigue syndrome were evaluated by the previous literature,and the evidence for medical treatment of chronic fatigue syndrome was provided.At the same time,the design of randomized controlled trials of acupuncture on chronic fatigue syndrome and the existing problems in methodology were explored to explore the relevant factors influencing the evaluation of the efficacy of acupuncture in the treatment of chronic fatigue syndrome and improve the quality of clinical research.Acupuncture treatment of chronic fatigue syndrome randomized controlled trials of the program design,data summary and research evaluation to provide reference.Methods:Based on the systematic review methodology provided by Cochrane,a scientific and effective search strategy was developed.All the literatures were searched and included in the standards-compliant study,data extraction,methodological quality evaluation and outcome index reporting With discussion.Retrieval methods and screening methods:computer,manual and other methods of electronic databases and magazines in the journal literature,dissertations and gray literature to retrieve,computer search electronic database were Web of Science,Medline,Cochrane Library,Embase,Psycinfo,ICTRP,Clinical Trails,CNKI,CBM,VIP,WANFANG,and "Journal of Acupuncture and Moxibustion","Chinese Journal of Acupuncture and Moxibustion","Chinese Journal of Acupuncture and Moxibustion","Journal of Acupuncture and Moxibustion" and "Shanghai Acupuncture and Moxibustion";In addition,through the scientific papers online and Open Gray to achieve gray literature or conference papers retrieval.The date of the search is from the building to December 30,2016.Finally,according to the literature,the author uses EndNote X7 document management software to remove weight,and then,according to the inclusion and exclusion criteria of the literature,by reading the title,abstract and full text,And finally selected to meet the inclusion criteria of the study.Data extraction and quality evaluation:data extraction and quality assessment of the data,both by the two evaluators independently completed,after cross-check,such as judgments,can be discussed or third-party ruling,all data results in tabular form.We apply the risk of bias tool to the methodology of the incorporated literature research.We do not only use the I2 statistic test,but also ?2 and its p-vaLue test;report bias,if the number of documents included in more than 10,the production of funnel map to assess the risk of bias,due to visual In the data merge,when I2 is less than 50%,the fixed effect model is adopted,and when I2 is larger than that of I2,when I2 is less than 50%,we use the fixed effect model.When I2 is less than 50%50%,the use of random effects model.Outcome index:The main outcome indicators included fatigue evaluation index,fatigue evaluation using FS-14,FSS,FAI scale.Secondary outcome indicators included quality of life assessment indicators,using SF-36,SF-20,SF-12 scale,and SAS scale.Results:Through the computer,manual way to journals,dissertations and gray literature to retrieve,access to literature titles,abstract 2656 articles.Using the EndNote X7 software,810 articles were removed and 1846 articles were included in the screening process.According to the inclusion and exclusion criteria of the literature,227 documents were read into the secondary screening process by reading the title,abstract,and reading the full text,The final inclusion of 14 articles,including English literature 2,Chinese periodicals 12,a total of 1033 cases of patients.1.In the randomized controlled trials of the five acupuncture control blanks,FS-14 was used as the endpoint,and acupuncture contrasted the blank control significantly improved the condition of fatigue,moderate heterogeneity,and low publication bias.In the randomized controlled trials of five acupuncture and acupuncture in the treatment of chronic fatigue syndrome,fatigue assessment was used as the end point.Acupuncture was more likely to improve the fatigue and heterogeneity of the subjects.Low bias.In the randomized controlled trials of acupuncture at acupuncture for the treatment of chronic fatigue syndrome,the fatigue score was used as the end point.Acupuncture was more likely to improve the fatigue and heterogeneity of the subjects.Low bias.2.In included studies four studies did not report adverse events,none of the participants included in the study reported no adverse events during treatment and follow-up.One study reported 2 adverse events and acupuncture directly Related,but mild symptoms;2 cases of serious adverse events and acupuncture has nothing to do.Conclusion:1.Acupuncture in the improvement of chronic fatigue syndrome,some of the symptoms of the exact effect.2.Acupuncture therapy of chronic fatigue syndrome has a certain safety,and in clinical applications have certain advantages. |
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