Study On The Relationship Between Hepatitis B Virus-Associated Fibrosis And Vascular Endothelial Function

Objective:To investigate whether there are differences in endothelial function in chronic hepatitis B with different degree of fibrosis.Methods: Collected the CHB patients in the First Affiliated Hospital of Xinjiang Medical University during January 2015 to December 2015,according the degree of liver fibrosis the patients were divided into four groups Vascular endothelial function was reviewed and reactive hyperemia index(RHI)was calculated by using peripheral arterial tension(PAT)detection with Endo-PAT2000,detect blood biochemical index the determination of transient elastography liver stiffness values(LSM).Analysis the relation between RHI and LSM by Pearson.Results: 61 cases were collected,including 8 cases in group S0,22 cases in group S1,20 cases in group S2,11 cases in group S3.The levels of RHI,LSM,low density lipoprotein cholesterol,total cholesterol,between four groups are compared with significant difference.RHI in group S0(1.93±0.30),RHI groupS1(1.78±0.38),RHI in group S2(1.63±0.13),the difference between the four groups was statistically significant(P=0.00).S0,S1,S2 group is higher than the levels of total cholesterol,low density lipoprotein total cholesterol compared to S3 group having significant difference(P < 0.05).Group S3 higher alanine aminotransferase,LSM compare to S0 group,S1,S2 group difference was statistically significant(P < 0.01).RHI and LSM are negatively correlated(r=-0.323,P =0.011).Conclusion: In CHB patients with liver fibrosis degree enhancement,RHI is reduce.elastic liver stiffness measurement LSM is negatively related to the RHI,CHB patients with the degree of liver fibrosis increased low-density lipoprotein,total cholesterol is gradually decreased.