Cryoballoon Ablation And Irrigated Radiofrequency Ablation For Patients With Paroxysmal Atrial Fibrillation:Systematic Review And Meta-Analysis

Objective:In view of the clinical efficacy of cryoballoon ablation ( CBA) and irrigated radiofrequency ablation(IRA ) in the treatment of paroxysmal atrial fibrillation Meta analysis, to explore the safety and recurrence of CB and IRA in the treatment of paroxysmal atrial fibrillation, to provide a reference for clinical treatment.Methods:Through the EMBASE, MEDLINE, HighWire, CCRT electronic databases to retrieve the clinical research data (December 2005 to December 2015), research data for catheter ablation of paroxysmal atrial fibrillation in patients with clinical research and test, according to the screening criteria, the articles were screened, extract the data, choose random effect model meta data analysis. Sensitivity analysis was carried out to study the characteristics and the quality of the literature, and the funnel plot was used to evaluate the literature publication bias.Results:The clinical study included 14 qualified clinical trials, There were respectively 469 and 674 patients referred for cryoballoon and radiofrequency ablations. Through analysis and statistics, the research department has significant heterogeneity (I2 = 0%, P > 0.05); Overall analyses indicated that cryoballoon ablation significantly reduced fluoroscopic time and total procedure time by a weighted mean of 14.13 minutes[P=0.014,95%CI(2.82,25.45 ) ] and 29.65 minutes[P=0.006,95%CI(8.54,50.77)] compared with radiofrequency ablation,respectively,whereas ablation time in cryoballoon ablation was nonsignificantly elongated by a weighted mean of 11.66 minutes[P=0.307,95%CI(-10.71,34.04)].Cryoballoon ablation was also found to be associated with the relatively low risk of having recurrent atrial fibrillation[P=0.538,RR=0.75 , 95%CI(0.3,1.88)]and major complications [P=0.269,RR=0.46 , 95%CI(0.11,1.83)].Conclusions:Cryoballoon ablation and irrigated radiofrequency ablation is an effective and safe operation way of the ablation of paroxysmal atrial fibrillation, but still needs further improvement and development.