On Theneed And Analysis Of High Risk Factors Affecting Prognosis For Radiotherapy After Modified Radical Mastectomy With T_1-2N₁M₀ Breast Cancer Patients

Objective: To explore To investigate whether T₁,T₂,metastatic lymph node 1-3,M0 breast cancer patients after radical mastectomy need radiotherapy and analyze the high factors affecting the prognosis.Methods: By studying 106 cases of breast cancer patients treated in Affiliated Tumor Hospital of Guangxi Medical University from December 2010 to January 2006,which was in line with the stage of breast cancer after modified radical mastectomy and chemotherapy.Patients were divided by category of radiotherapy treatment,i.e.the radiotherapy group?44 cases?,and the control group who receive no radiotherapy?62 cases?.Information was collected in terms of the local recurrence rate?LRR?,the distant metastasis rate,?DMR?the disease-free survival rate?DFS?and the overall survival rate?OS?over a span of 5 years.Analysising of risk factors affecting prognosisResults: The 5-year local recurrence rate,the distant metastasis rate ofthe radiotherapy group was lower than that of the non radiotherapy group.The5-year disease-free survival rate was higher than that of the non radiotherapy group,whereas the 5 year overall survival rate was not statistically significant between the 2 groups.Postoperative radiotherapy was an independent prognostic factor for LRR and DFS,The risk of local recurrence and disease-free survival in patients without radiotherapy were higher than those without radiotherapy.Sex hormone receptors?HR?status is an independent prognostic factor for DMR,OS,and positive for receptor positive patients.The intensity modulated radiotherapy group and the conventional radiotherapy group had no difference in LRR,DMR,DFS and OS for 5 yearsConclusion: For T₁,T₂,lymph nodes 1-3,M0 breast cancer patients,after radical resection,radiotherapy is recommended.Radiation therapy.Whether or not IMRT is better after modified radical mastectomy is worthy of further study.The sex hormone receptor status is an independent factor affecting the survival index.