The Analysis Of The Clinical Result Of A Randomized Clinical Trial Comparing Breast Conservation Therapy And Modified Radical Mastectomy

Objective:By analyzing the clinical result of a randomized clinical trial That has been resulted from comparing Breast Conservation TheraPy With Modified Radical Mastectomy, this research is to discuss the best Method applied in the treatment of early breast cancer. Methods:This study retrospectively analyzes 181Patients with early breast cancer in our hospital from Mar.2004toSEP.2005.All of these Patients were female and these patients of 1stage and 2stage, These Patients were between 22 and 64years old,with the average age 43. According to the method operated on them,they were divided Into two groups,the group of Breast Conservation Therapy and the group of Modified Radical Mastectomy. In the group of Breast Conservation Therapy,There were 79 Patients with the age between 22to61 and the average age of 41.5, including 46 cases of 1stage and 33cases of I stage,All of The must be Performed by adjuvant radiotherapy, and much more dose was Performed in the base area of tumor. In the group of Modified radical mastectomy,there were 102cases with the age between25and64 and the average age of44.5 , including53 cases of 1 stage and 49 cases of 11stage, In addition,the radiotherapy scope of modified radical mastectomy was determined by both the size of the tumor and the lymph node metastasis. The patients of both two groups were performed chemotherapy ,and Rx mainly was CEF. The Patients whose ER/PR Were Positive Were Performed incretion therapy, .In the two groups,there was no obvious Statistic difference (P>0.05) by analyzing all of the data, including age and stage. By comparing these two groups'local recurring rate,distant metastasis rate and survival rate of 3years, the Research was evaluating the therapy effieieney. Results:In the group of breast conservation therapy,the 3 year local recurring rate is 2.5%,distant metastasis rate is 1.2%,and Survival rate is 97.4%,In the group of modified Radical mastectomy, the 3 year local recurring rate is3.9%, distant metastasis rate is 4.9%,and Survival rate is 95%, There is no obvious difference between the two groups(P >0.05).Conclusion:For Patients withearly stage breast cancer , combining radiotherapy can achieve the same result as the traditional modified radical mastectomy and Breast conservation therapy also has more advantages,such as less wound, lighter Pain, quicker recovery, and higher quality of living etc. Therefore,the should be considered as a preferable method of treating early breast cancer·...