The Effects Of Controlled Hypotension Combined With Tranexamicacid On Peri-operative Blood Loss And Coagulation Function In Patients Undergoingbrain Tumor Surgery

Objective: To investigate the effects of controlled hypotension(CH)combined with tranexamic acid(TA)on peri-operative blood loss and coagulation function in patients undergoing brain tumor surgery.Methods: Forty patients undergoing brain tumor surgery were randomly allocated into group A and group B with 20 patients in each group.Patients in group A received controlled hypotension alone,while patients in group B received controlled hypotension combined with tranexamic acid.Coagulation factors and d-dimer levels were measured 24 hours before and after surgery.Amount of blood loss,intravenous fluid transfused,urine output and postoperative drainage were recorded.Results: Ingroup B,D-dimer levels of 24 hours after surgery(0.91±0.36)mg/L increased compared with that of 24 hours before surgery(0.33±0.12)mg/L.And in group B,the D-dimer level increased more than that of group A(P<0.05).But no significant difference was found in coagulation factor levels between group A and group B.Amount of blood loss(485.1±23.7)ml,intravenous fluid transfused(256.4±41.5)ml and postoperative drainage flows(196.1±89.4)ml of patients in group B were lower than thatin group A(613.3±42.4)ml,(415.6±34.7)ml,(289.2±78.5)ml.Differences were statistically significant(P<0.05).Besides,there were no significant changes in urine output and fluid infusion volume between two groups.Conclusions: Controlled hypotension compared with tranexamic acid can reduce perioperative blood loss in patients undergoing brain tumor surgery,with no obvious coagulant function abnormality.Collectively,it should be a safe and reliable method for clinical application.