Application Of Pickering Emulsion In Drug Microcapsules

To solve the problem of waste of resources and environmental pollution caused by the burning or discarding of plant stalks (such as corncobs) as agricultural wastes, we have further chemical modification of the corncobs treated by steam blasting That is, TEMPO oxidation), the treated corncobs were increased in water solubility and had a certain pH responsiveness; then we used TEMPO to oxidize the cellulose to prepare a stable Pickering emulsion and again modified the oxidized cellulose to prepare a magnetic nano The results showed that the antibacterial properties of Pickering emulsion were confirmed by freeze scanning electron microscopy and fluorescence confocal microscopy. Finally, the oxidized cellulose colloid particles adsorbed on the interface of oil and water were fixed by polymer co-precipitation technique. The microcapsules thus prepared have a certain volume of space. The main works of this paper are:(1) Different oxidized degree (DO) of cellulose nanoparticles (DO30,DO50, DO100) were prepared by the oxidation of C-6 hydroxyl groups on the cellulose polysaccharides by TEMPO oxidation technology, and the degree of oxidation was precisely controlled.(2) Through the evaluation of in vitro cytotoxicity of oxidized cellulose nanoparticles, it was verified that TEMPO oxidation technology did not bring toxicity to cellulose and belong to green, materials.(3) Through the surface tension and contact angle experiments,indicating that oxidized cellulose can reduce the oil and water interface tension and contact angle, and thus can be used to prepare Pickering emulsion. And identified by freeze scanning electron microscopy and fluorescence confocal microscopy and to determine the success of the preparation of a stable Pickering emulsion.(4) The Pickering emulsion with magnetic response was prepared by chelating the carboxyl groups on the surface of oxidized cellulose and iron ions in ferric oxide. The prepared Pickering emulsion was confirmed by fluorescence confocal experiment and magnetic response experiment.(5) By means of Pickering emulsion template method and polymer precipitation technology, a series of experimental conditions were selected, including the selection of emulsification technology and optimization of oil-water volume ratio. Finally, cellulose microspheres with uniform particle size were prepared by PLGA.