Clinical Analysis Of Risk Factors And Maternal–Fetal Outcome In Hypertensive Disorder Complicating Pregnancy

Objective: To study the risk factors of hypertensive disorder complicating pregnancy and the adverse pregnancy outcome,to explore the reasonable treatment of hypertensive disorder complicating pregnancy,to provide clinical guidance for clinical diagnosis and treatment of the disease.Methods: A large sample of retrospective analysis of the research method,collected in January 2015 to December 2016 in the first hospital in Lanzhou University Obstetrics and Gynecology,a clear diagnosis of hypertensive disorders of pregnancy,while the smooth delivery of maternal 436 cases as observation group,and the other randomly selected the same period of time in our hospital gynecological hospital delivery,and the pregnancy of the clinical test indicators were normal 436 cases of pregnant women as a control group.Details of the general situation of the two groups of pregnant women,the outcome of delivery,perinatal outcome,clinical test indicators(blood,coagulation function)and other information.Data were analyzed by independent sample t test,χ2test and multivariate unconditional logistic regression analysis.Results: 1.The mean age of the observation group was higher than that of the control group,the difference was statistically significant;the age of the pregnant women was ≥35 years old,the proportion of the two groups was 44.50%,36.24%,the difference was statistically significant;2.Twelve cases of pregnancy,the two groups were 13.30%,4.82%,the difference was statistically significant;3.The proportion of pregnant women in observasion group after IVF-ET and control group was 16.51% and 6.65%,respectively,the difference was statistically significant;4.Standardized test,the two groups were 52.06%,68.35%,the difference was statistically significant;5.Culture level(college and above),the two groups were 40.60%,56.20%,the differencewas statistically significant;6.Obesity(pre-pregnancy BMI ≥ 28Kg/m2),the two groups were 50.23%,43.12%,the difference was statistically significant;7.White blood cell count and its classification(lymphocytes,neutrophils),the average group were higher than the normal pregnancy group,compared to the difference between the two groups were statistically significant;mild preeclampsia group and severe preeclampsia group White blood cell count and its classification of the mean,the difference was not statistically significant;8.The mean value of PLT,PT,APTT and TT in the disease group was lower than that in the normal pregnancy group,the mean value of FIB was higher than that of the normal pregnancy group.The difference was statistically significant.The mean values of PLT,PT,APTT and TT in mild preeclampsia group were lower than those in severe preeclampsia group,and the mean value of FIB was higher than that of severe preeclampsia group.The difference was statistically significant;9.Multivariate unconditional logistic regression analysis of the above-mentioned significant univariate factors showed that: Age,twin pregnancy,test-tube infants,pre-pregnancy BMI,leukocyte,neutrophil,PLT,PT,FIB is the risk factor for HDCP onset,and standardized production and cultural level is the protective factor of HDCP;10.The incidence of preterm labor,cesarean section and postpartum hemorrhage were38.30%,62.61% and 31.65% in the disease group,21.10%,47.25% and 17.43% in the normal pregnancy group,respectively,The difference was statistically significant;11.The incidence of fetal growth restriction,fetal distress,neonatal asphyxia and perinatal mortality were 22.25%,33.72%,16.51% and 4.13% respectively in the neonates of the disease group,and the rate of the perinatal outcome of neonates in the normal pregnancy group was12.39%,22.02%,8.49%,0.46%,the difference between the two groups was statistically significant;Conclusion: 1.Old age(age ≥35 years),multiple births,test-tube babies,obesity may be the risk factors for the incidence of hypertensive disorder complicating pregnancy;2.There is a certain correlation in Leukocyte count and its classification and the incidence of hypertensive disorder complicating pregnancy;3.PLT,PT,FIB can reflect the severity of hypertensive disorder complicating pregnancy.Monitoring platelet and coagulation in patients with hypertensive disorder complicating pregnancy can keep abreast of the progress of the disease and prevent the occurrence of serious complications and reduce the incidence of adverse pregnancy;4.So far,in addition to termination of pregnancy,there is no effective treatment for PE.Therefore,reliable predictors of PE will play an important role in early prevention and intervention,but their reliable predictors need to be further excavated.