The Effect Of Hypertension During Pregnancy On Maternal And Infant Outcomes

Objective:Hypertensive disorders of pregnancy(HDP)is a group of diseases in which pregnancy and blood pressure coexist.HDP is still one of the main reasons leading to an increase in the mortality rate of pregnant women and perinatal children.This study intends to analyze the clinical manifestations,epidemiological features,and pregnancy outcomes of 107 HDP-pregnant women admitted to the affiliated hospital of Jiangsu University from December 2015 to December 2017 to investigate the effects of different types of pregnancy-induced hypertension on pregnancy outcomes and outcomes.The influence of children provides a scientific basis for better prevention and control of hypertensive disorders during pregnancy and the protection of maternal and child health.Serum endothelin-1(ET-1),epidermal growth factor(EGF)and mean arterial blood pressure(MAP)levels were measured in the observation group and the control group.Method:107 pregnant women with HDP admitted to wujin hospital of jiangsu university from December 2015 to December2017 were selected as the observation group,and 100 pregnant women without hypertension complications during the same period of hospitalization and delivery were randomly selected as the control group.The rates of cesarean section,preterm birth,postpartum hemorrhage,fetal distress,low birth weight,neonatal asphyxia,and perinatal death in the observation group and the control group,as well as in the observation group,were statistically analyzed to determine whether there were statistical differences between the two groups.Finally,multivariate analysis of HDP risk factors was performed.Result:The rates of cesarean section,preterm birth,postpartum hemorrhage,fetal distress,low birth weight,neonatal asphyxia,and perinatal death in the observation group were significantly higher than those in the control group(P<0.05),and the difference between the two groups was not statistically significant(P>0.05).The rates of cesarean section,preterm birth,postpartum hemorrhage,fetal distress,low birth weight,neonatal asphyxia,and perinatal death in patients with preeclampsia were significantly higher than those in patients with gestational hypertension(P<0.05).The rates of cesarean section,preterm birth,postpartum hemorrhage,fetal distress,low birth weight,neonatal asphyxia,perinatal death and maternal death in patients with HDP complications were significantly higher than those without complications(P<0.05).Advanced age,nonstandard prenatal examination,high school education or below,BMI≥25.0 kg/m~2,and primipara are risk factors for the onset of HDP(P<0.05).The levels of ET-1 and MAP in the observation group were significantly higher than those in the control group and the difference was statistically significant(P<0.05).The EGF level was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).There was a significant positive correlation between ET-1 level and MAP in the observation group(r=0.936,P=0.000),and EGF level was significantly negatively correlated with MAP(r=-969,P=0.000).Conclusion:HDP can cause a variety of adverse pregnancy outcomes.Correct understanding of the occurrence law of HDP can reduce the incidence of adverse pregnancy outcomes.Et-1 and EGF in HDP are significantly correlated with the mean arterial pressure of pregnant women,which is expected to be a new target for the prevention and treatment of HDP.