The Relationship And Clinical Significance Of Chromothripsis And Blood Tumor

With the development of social economy,the progress of human science,the improvement of medical technology,a detection is improved,the incidence of tumor and to prove the existence of chromosomes fracture associated with tumorigenesis,chromothripsis broken English terms of chromosomes.Studies found that chromothripsis fractured(chromosome)are cells catastrophic events,the development of it in to the tumor cells play an important role in the process.In the past ten years,the global genome sequencing has confirmed that the vast majority of the occurrence and development of cancer,is the result of a series of gradual genetic aberrations accumulate.Studies have shown that the change of the chromosome and the genes,so that a gradual change,DNA repair mechanisms can eventually lead to the change of cell fate,and makes the cells in the survival process evolved into cancer cells.In 2011,Stephens and others through genomics studies have found that cell chromosome genes involved in the process of an incident big changes to dozens or even hundreds of genome rearrangement,we call this event chromothripsis events.Like the source of the nouns in the following two the meaning of English words,such as’ chromo came from the word ’chromosome;Words’ thripsis for shattering into pieces,namely the cracked into flake.Chromosome fragmentation events can occur at several chromosomal region,produced a large number of chromosome fragments and produces natural repair itself.In the process of this event,many of the pieces can be lost from the cells,the remaining fragments will reconstitute incoherent chromosome monomer.It is interesting to note that chromosomes fracture occurs,the cells can not only survive in the genetic damage of disaster events,and can also appear in the process of inhibition of tumor suppressor genes and proto-oncogenes activation.Chromosome fragmentation events in the incidence of cancer of about 2-3%,therefore,if it is found that the chromosome fragmentation events related mechanism,for clinical diagnosis and treatment of tumor patients and clinical prognosis of quite important significance.In addition,the chromosome fragmentation events can also occur in the patients with non tumor disease,so,today the latest research results and findings of chromosome fragmentation events for understanding the occurrence and development of tumor has an important influence.