Research On The Improved Accessories ? Of Which Compound Wood Turtle Sustained Release Tablets

Objective To establish a method for sampling powder containing sustained-release tablets suspension and in vitro release assessment method for powder-containing sustained-release formulation.And to provide the basis for the study of therelease rate of the Improved accessories ?slow-release tablets.Methods(1)Powder evenly distributed in the suspension to obtain a homogeneous sample was prepared by the sampling syringes with 10 ml red suspension technology.(2)The slurry were adopted dissoluted test,with water as dissolvent,100r/min,Using HPLC,The column was an Eclipse Plus C18 column(4.6 x 250 mm,5?m),Detection wavelength of 245 nm,Mobile phase: acetonitrile: 0.085% phosphoric acid gradient elution,Column temperature: 30?,To investigate the release mechanism of dissolved granules from 0 ~ 30 min after 2h,4h and 8h removal of tablets.And the cumulative release percentage of compound wood turtle sustained-release tablets was measured,and the cumulative release curve was drawn and the release degree of the samples was evaluated.Under the same chromatographic conditions,the changes of the absorption peak were investigated by HPLC analysis of single herb and compound compound in softwood.(3)Study on the effects of different dosage and usage of modified auxiliary materials on the release of compound soft-shelled turtle.(4)Evaluation of the sustained-release properties of different crushed tablets by the molding and release of compound wood turtle tablet.Results(1)The best sampling methods by 10 ml syringe red suspension 5 times below the surface and in 2/3.(2)The release of peak 1,peak 2 and peak 3 was consistent with the Ritger-Peppas release model at 0 ~ 15 min after 2h,4h and 8h removal of the tablet;In vitro release of the main dissolution of the dissolved particles(powder)release about 15 minutes,remove the tablet before the compound wood turtle sustained-release tablets total release 2h-6h meet the zero-order equation,remove the dissolved powder after the release of the release of the tablet Consistent with Higuchi equation.The cumulative dissolution rate of tablets for 8 h was 97.47%.Single herbs have no obvious absorption peak,mixed herbs appear stable new absorption peak.(3)By comparing the cumulative release percentage of the three different dosage of compound wood turtle sustained-release tablets,it was found that the cumulative release rate of the compound wood turtle sustained-release tablets was 20% and 40%at 20% Fast,improved auxiliary materials with 30% and 40% of the compound wood turtle sustained-release tablets at different times the cumulative release rate close to,so choose the amount of 30% as a compound wood turtle slow release tablets accessories.The cumulative release rate of the compound wood turtle sustained-release tablets at different times was slower than that of the method 1 and the usage 3,the improved release rate of the modified materials ? and the compound 3 of the compound wood turtle sustained-release tablets at different times Close,so choose to use 2 as a compound wood turtle slow release tablets accessories best usage.(4)The higher the number of tablets,the deeper the particle color,the more delicate the powder,the deeper the color of the tablet,the more smooth the surface,the greater the hardness of sustained-release tablets,the better the slow release performance.Conclusion The release of the whole powdery compound soft-shelled turtle shell is a dissolution-dissolution process,which achieves a balanced release.Single-drug compatibility with the composition of the compound,the UV absorption changes,indicating the complexity of traditional Chinese medicine compound basis.The content determination method can be used to evaluate the release rate of compound wood turtle sustained release tablets.