Study On Compound Curcumin Capsule Based On Nanocrystalline Crystallization Technology

Objective: Curcumin(CUR)mainly from the ginger Branch,Araceae in some plants,for the polyphenols.Curcumin in reducing blood lipids is not only effective and safe and reliable.But curcumin is insoluble in water,low bioavailability,in the neutral to alkaline p H conditions unstable,sensitive to light,heat,iron ions.Hawthorn and hawthorn flavonoids have a good lipid-lowering effect,clinical application tips,turmeric and hawthorn combination can achieve better lipid-lowering effect.In this paper,curcumin was used to prepare curcumin nanometer suspension by using planetary ball mill to improve the solubility and bioavailability of curcumin.The nano-suspension was prepared by wet granulation into solid particles,The extract was mixed with capsules to obtain compound curcumin capsules.Methods: The content of active ingredients in curcumin and hawthorn was determined by high performance liquid chromatography(HPLC),and the curcumin dissolution test was screened.The method of in vitro analysis of curcumin capsules was established.The grinding parameters were screened and the parameters were determined.The results showed that the dissolution rate of granules was 15,45 and 90 min,and the curvature of curcumin was determined by Box-Behnken response method.The particle size distribution and crystal morphology of the prepared curcumin nanosized suspension were characterized by laser particle size measurement,differential calorimetry,electron microscopy,X-ray powder diffraction and Raman spectroscopy.The pharmacokinetic parameters of curcumin capsules and curcuminous raw materials and hawthorn extract were studied.The pharmacokinetic parameters of curcumin in SD rats were analyzed and the pharmacokinetic parameters were analyzed.Results: 1.Determine the dissolution medium as p H 4.5 acetate buffer solution(containing SDS 0.5%,m / v),dissolution speed of 50 r·min-1,dissolution medium volume of 1000 m L;establishment of curcumin dissolution determination method,turmeric The results showed that the linearity was good in the range of 0.041-0.431 ?g(y = 113.34 x – 1.3398,R2 = 0.9991).The results of precision,recovery and solution stability were in accordance with the requirements of pharmacopoeia.The results showed that the content of curcumin in the range of 0.098-0.689 ?g(y = 95.603 x-0.7711,R2 = 1.0000)was good,and the content of chlorogenic acid was 1.470 – 8.085 ?g(y = 24.537 x + 1.2103,R2 = 0.9997),the linearity of Vitexin in the range of 0.490 – 2.698 ?g(y = 5.2783 x – 0.3904,R2 = 0.9998)is good,the precision,the recovery rate,Solution stability test results are in line with pharmacopoeia requirements.2.The effect of P 188,copovidone S 630 and cross-linked povidone XL-10 was determined by influencing factors.Finally,the CUR content was 10% in the grinding fluid,the grinding time was 3 h,the grinding speed was(About 145 g),the diameter of the grinding ball is 0.5 mm: 1 mm: 3 mm = 0.5: 3: 0.5(v / v,the total mass is about 145 g).3.Using Box-Behnken response surface method to optimize the formulation of curcumin nanocrystals.The results showed that the dosage of P 188 in curcumin nanosized suspension was 2.98%,the amount of copovidone S 630 was 0.1%,the dosage of crospovidone XL-10 was 1.40%,and the compound curcumin In vitro dissolution of capsules.The compound curcumin capsules were prepared and the quality of the capsules was evaluated.The results were in accordance with the standard.4.The results of laser particle size analyzer showed that the particle size distribution of curcumin was concentrated.The appearance of curcumin nanocomposite freeze-dried powder was observed by scanning electron microscopy(SEM).The results showed that the distribution of curcumin was uniform and the results were analyzed by differential scanning calorimetry The curcumin did not undergo chemical reaction with the excipient after grinding.The results of X-ray powder diffraction and Raman spectroscopy showed that the crystal form of curcumin did not change after grinding.5.Pharmacokinetic test results show that compound curcumin capsules can improve the absorption of curcumin in rats and improve its bioavailability.Conclusions: In this study,the curcumin capsules can be used to evaluate the quality of compound curcumin capsules.The curcumin powder in compound curcumin capsules can be stabilized and the solubility of curcumin can be effectively improved.The preliminary results of pharmacokinetic study show that the preparation Can effectively improve curcumin bioavailability.