Numerical Analysis Of Bone Remodeling Threshold Changes On Renal Osteodystrophy

Kidney is one of the important regulating organs,bone metabolic disorder caused by renal damage named renal bone disease.Renal bone disease(RBD)is a metabolic bone disease caused by chronic renal failure and the calcium phosphorus metabolism disorder.So far,there are few research on quantitative relationship between renal bone disease of bone metabolic biochemical index and bone quantitative bone mechanical properties.The purpose of this article is to build the quantitative relationship between renal bone disease of bone metabolic biochemical index and trabecular bone.For the purpose of building a quantitative relation between Renal bone disease of bone metabolic biochemical index and Bone mechanical properties,eight specific biochemical indicators and quantitative experimental data of there respective affect bone metabolism were summarised from a large number of literature about renal osteopathy,then inevitable in the process of experiment and result in missing data for the supplement,completing the data,which was to facilitate the next analysis.Based on the acquired data and the theoretical equation of weinan bone reconstruction,calculated by Bone reconstruction threshold under different states of different conditions.Principal component analysis method is used to eliminate the linearity in eight variables,using multiple linear regression model,take the data to carry on the multiple linear regression analysis,getting bone reconstruction threshold of biochemical indicators of multiple linear regression equation.Writing the corresponding program by the software,on the basis of compare between bone reconstruction threshold according to different conditions is worth the bone mineral density and actual changes in bone density in the literature,the two trendlines are more like;The results verify the rationality of bone reconstruction threshold and availability.This paper mainly studied the quantitative relationship between renal bone disease of bone metabolic biochemical index and trabecular bone mechanical properties,established multiple linear regression equation of bone reconstruction threshold which was related to eight biochemical indicators of renal bone disease.The finite element simulation and the cases of the literature verified the availability of bone reconstruction threshold,which make it possible to infer the changing trend of bone mineral density while in the condition of knowing renal bone disease biochemical index value.