Expression Of TIM-4 In Colorectal Cancer And Its Relationship With Clinical Pathology And Prognosis

ObjectiveTo study the expression of T cell immunoglobulin domain and mucin domain protein 4 in colorectal cancer(CRC)in T cells,and to explore the relationship between the clinical pathological features and prognosis.MethodImmunohistochemistry was used to detect the expression of TIM-4 in 197 cases of colorectal cancer(CRC)and normal colorectal epithelial tissue microarray,and the expression levels of TIM-4 in 192 cases of colorectal cancer were analyzed in the the cancer genome atlas(TCGA)database.Data were expressed as mean±standard deviation,((34)±SD),and analyzed by Student’s t-test by SPSS22.0 software,the size of test was 0.05.Result1.TIM-4 was expressed in colorectal cancer microenvironment tissues and normal colorectal epithelial tissues,the expression level of colorectal cancer was significantly higher than that of normal colorectal epithelium(P<0.01);2.The expression intensity of TIM-4 in colorectal cancer tissues was correlated with tumor pathological grade(P<0.05),TNM stage(P<0.001),clinical stage(P<0.001),lymph node metastasis(P<0.001)and distant metastasis(P<0.01),however,it was not related to gender and age(P>0.05);3.The expression of TIM-4 in 192 colorectal cancer patients with the cancer genome atlas(TCGA)was associated with tumor stage(TNM)(P<0.05),and had no relation with sex,age,pathological grade,clinical stage,lymph node metastasis and distant metastasis(P>0.05).4.Kaplan-Meier survival analysis showed that the survival time of patients with high expression of TIM-4 was significantly shorter than that of patients with low expression(P<0.05);High expression of TIM-4 is an independent prognostic factor for colorectal cancer.ConclusionsTIM-4 may play an important role in the differentiation,invasion andmetastasis of colorectal cancer,is one of the poor prognostic factors in patients withcolorectal cancer.