Study Of The Construction Of Polypyrrole Micropattern And Its Properities

In biosensor and tissue engineering,the substrate with patterned conductive polymer film is a very attractive platform.A number of studies have proposed great potential for patterned materials in tissue engineering.One of the great advantages of patterned substrate can promote cell orientation,such as the arrangement of muscle fibers or bone tissue and morphological clues of promotion of proliferation,While patterned biomaterials for bone tissue are rarely studied.Patterned conductive polymer materials have been extensively studied in biosensors and tissue engineering.In this study,polypyrrole(PPy)micropattern was constructed on the template and the exploration of PPy micropattern on cytobiology and glucose biosensor.The design and construction of materials have important scientific guiding value for the combination of biosensor and tissue engineering applications.In this study,the following methods were developed for patterned polypyrrole on titanium surface:Firstly,through nanostructures functionalization of surface on porous titanium scaffold,with different nanostructures of porous titanium scaffold.The study of material and biological properties shows that nanoplate nanostructure has good biocompatibility.On this basis,the nanostructures of surface functionalized nanostructures were obtained on the surface of biomedical titanium sheets.Titanium / TiO2 micropatterns were constructed as template by controlled laser ablation method,the conductivity between the sodium titanate and the titanium layer is 8 orders of magnitude difference,providing a basis for subsequent selective electrochemical polymerization on the surface of the template.Secondly,the template with different conductivity is used to construct PPy micropattern with nanostructures,with precise control of the nanostructured PPy and a flexible micropattern method.The method in this paper provides a new idea for PPy patterning.As the redox of PPy,the surface potential of PPy could be regulated to form surface potential difference with sodium titanate could constitute biomimetic microscale electric field.Finally,the biological properties of the micro-patterned materials were studied,and the basic biological properties of the micropattern surface as biomaterials were proved,and the application of PPy micropattern as glucose sensor,which provides an opportunity for the combination of biosensor and tissue engineering.