| Objective: Retrospective analyze the clinicopathologic characteristics and Prognostic factors of liver metastasis from gastric cancer further,we expect to clarify the relations between distribution of liver metastasis and gastric cancer,which maybe helpful to give a new insight into the treatment and prediction of liver metastasis from gastric cancer.Methods: Retrospective analyze the case information of liver metastasis from gastric cancer,which collected from medical records room of Fourth Hospital of Hebei Medical University during January 2001 and January 2014.The clinicopathologcal parameters of liver metastasis from gastric cancer were recorded accurately:(age and sex of Patients,tumor location,tumor size,tumor gross type,serosa invasion,histology type,tumor grade,vascular invasion,lymPh node metastasis,peritoneum metastasis,quality of operation,Liver metastasis location and Liver metastasis time).Establishment of a database of clinical and pathological characteristics of primary hepatic metastasis from gastric cancer with EXCEL,Read some cases,These Patients were followed up regularly.SPSS21.0 software package is used for statistical analysis software.The Prognostic factors and correlation between other clinicopathologic characteristics were investigated.The association of clinicopathologic factors were evaluated by chi-square test.The logistic analysis was used to evaluate the influential factor of liver metastasis.The level of significance was P<0.05.Results:1 Sex ratio was 2.03:1 in the liver metastasis of gastric cancer,with a mean age of 58 year.The tumor were located in the gastric cardiac 206(43%);tumor size larger than 5cm 287(60.2%);serosal invasion 317(66.3%),Poorly differentiated adenocarcinoma 380(79.4%),moderately differentiated adenocarcinoma 92(19.3%),highly differentiated adenocarcinama 6(1.3%),vascularinvasion317(66.3%),Bormann I type 72(15%),Bormnann II type 87(18.3%),Bormnann III type 299(62.5%),Bormnann IV type 20(4.2%),Lymph node metastasis 436(91.2%),Peritoneum metastasis 26(26/117,2.2%),Radically operation 24(24/117,20.5%),Transferred to left lobe of liver 30(30/117,25.6%),Transferred to right lobe of liver 37(37/117,31.6%),Transferred to both lobes of liver 50(50/117,42.7%);Synchronous liver metastasis 38(38/117,32.5%),Metachronous liver metastasis 79(79/117,82%),Metachronous liver metastasis occurred from 1 to 34 months,with an average of 8 months.Found 11AFP-producing gastric cancer,there were 6 liver metastases(6/11,54.55%).(2)Sex ratio was 1.37:1 in the liver metastasis of colorectal cancer,with a mean age of 58 yr.The tumor were located in the right colon cardiac 52(52/128,40.6%),The tumor were located in the left colon cardiac76(76/128,59.4%): Tumor size larger than 5cm58(58/128,45.3%);Serosal invasion 39(39/128,30.5%),Well-differentiated adenocarcinoma 65(50.8%)vascular invasion 87(87/128,68.0%),Lymph node metastasis85(85/128,66.4%),Peritoneum metastasis 103(21.6%),Radically operation 104(21.8%),Transferred to left part of liver 95(19.8%),Transferred to right lobe of liver163(34.2%),Transferred to both lobes of liver 220(46%).Synchronous liver metastasis 141(29.6%),Metachronous liver metastasis 337(70.4%),Metachronous liver metastasis occurred from 1.2 to 38 months,with an average of 9months.2 Gastric primary tumor between the liver metastasis shows no signi-ficant correlation by chi-square test.This group shows no significant correlation by Chi-square test(P>0.05).Conclusion:1 The liver metastasis were significantly correlated with vascular invasion,lymph node metastasis,serosal invasion,peritoneum metastasis and Liver metastasis time.However,serosal invasion,peritoneum metastasis and Liver metastasis time were independently influential factors of liver metastases.2 Gastric primary tumor site has no significant difference compared withliver tumor site;The primary cancer in right half of colorectal more easily transferred to right lobe of liver and The left half primary cancers more easily transferred to both right and left lobes of liver.There is no significance between the primary site of gastric cancer with liver metastasis and the site of metastasis. |
PDF Full Text Request