Applied Research Of Multi-voxel ~1H-MRS Was Used To Assess The Range Of Glioma Tumor Cell Infiltration

Objective:To investigate the predictive value of multivoxel proton magnetic resonance spectroscopy(1H-MRS)in discussing the metabolic changes in peri-enhancement regions of brain gliomas.To evaluate the role of Multi-voxel 1H-MRS in assess the range of glioma tumor cell infiltration.Methods:Twenty-five cases with glioma confirmed by pathology were studied.According to the WHO diagnostic criteria,all cases were categorized into two groups,low grade gliomas(grade I,II)and high grade gliomas(grade III,IV).According to MRI manifestations,all cases were categorized into three groups(Tumor enhancement regions,peritumoral regions and normal rganization groups).All of them underwent 1H-MRS examination before operation.The variety of metabolite peaks were detected in different areas.Results:(1)Significant differences were found in the ratios of Cho/Cr,Cho/NAA between enhancement regions and normal brain tissues of low grade gliomas(P<0.05).Significant differences were found in the ratios of Cho/Cr,Cho/NAA between peritumoral edema regions and normal tissue in contralateral hemi-spheresof low grade gliomas(P<0.05).(2)Significant differences were found in the ratios of Cho/Cr,Cho/NAA between enhancement regions and normal brain tissues of high-grade gliomas(P<0.05).Significant differences were found in the ratios of Cho/Cr,Cho/NAA between peritumoral edema regions and normal brain tissues of high-grade gliomas(P<0.05).Conclusion: It's significance of Multi-voxel 1H-MRS can assess the range of tumor cell infiltration and assess the distribution of glioma tumor cells.