The Levels Of Circulating Betatrophin In Women With Polycystic Ovary Syndrome Are Decreased And Associated With Insulin Resistance

Objective: The study was to investigate circulating betatrophin levels in women with Polycystic Ovary Syndrome(PCOS)and the correlation with insulin resistance.Methods: Forty-four women with PCOS and thirty-five healthy women were recruited in a cross-sectional study.Serum concentrations of betatrophin was measured by enzyme-linked immunosorbent assay.The correlation of betatrophin with insulin resistance and metabolic parameters was also analyzed.Then twenty-seven PCOS patients were studied longitudinally after three mouths of metformin and rosiglitazone sodium treatment.Results: Serum betatrophin levels were lower in PCOS patients than that in healthy control subjects(0.43±0.15 ng/m L vs 1.17±0.57 ng/m L,P<0.001).Serum betatrophin negatively correlated with FPG,2h PG,FINS,HOMA-IR,hs-CRP,even after controlling for age and BMI in PCOSparticipants(all P<0.05).Moreover,stepwise multiple regression analysis showed that HOMA-IR was independently related to betatrophin in PCOS subjects(P<0.05).After rosiglitazone sodium and metformin treatment,PCOS patients showed higher betatrophin concentrations than its baseline levels(0.87±0.51 ng/ml vs 0.42±0.17 ng/ml,P<0.001).Conclusion: Circulating betatrophin levels were decreased in patients with PCOS,and associated with insulin resistance.