Relationship Between Serum Vitamin D And Senile Diabetic Peripheral Neuropathy

Objective:To evaluate the associations of 25-hydroxy vitamin D3(25OHD3)with peripheral neuropathy in elderly type 2 diabetes patients.Methods:A total of 150 elderly patients with type 2 diabetes mellitus were enrolled in the study,including 89 subjects with diabetic peripheral neuropathy(DPN)and 61 subjects without DPN(NDPN).Their clinical data were collected.Fasting blood samples were collected for estimation of 25(OH)D3 by chemiluminescent immunoassay.Results:The mean serum vitamin D in the DPN group [(11.89±6.26)ng/ml] was significantly lower than that in the NDPN group [(17.05±6.14)ng/ml,P<0.001] and 88.76% of patients with neuropathy had vitamin D deficiency compared with 66.85% of NDPN patients(P<0.01).The age,diabetes of duration,fasting plasma glucose,Hb A1 C,total cholesterol,low-density lipoprotein cholesterol were higher in the group of neuropathy.Serum vitamin D showed significantly negative correlations with duration of diabetes,Hb A1 c,UACR(P<0.05).Logistic regression analysis showed that 25(OH)D3 were negatively correlated with DPN,while the diabetes of duration and Hb A1 c were positively correlatide with DPN.Conclusions:The level of 25(OH)D3 is closely associated with the occurrence of diabetic peripheral neuropathy.Further studies are required to figure out if vitamin D supplementation could delay the onset or relieve the clinical symptoms.