Correlation Between Serum FGF21 Level And Peripheral Neuropathy Of Type 2 Diabetes

Objectives This study measured the levels of fibroblast growth factor 21(FGF21),superoxide dismutase(SOD),malondialdehyde(MDA),tumor necrosis factor-α(TNF-α),and other indicators in the serum of patients with type 2 diabetic peripheral neuropathy(DPN),to study the correlation between these factors and DPN,and to explore whether FGF21 can affect the occurrence of DPN by regulating oxidative stress and inflammation.Methods A total of 200 patients with type 2 diabetes mellitus(T2DM)who were treated at Hebei General Hospital from November 2019 to November 2020 were selected as the research objects.According to symptoms and signs,109 patients were divided into the simple type 2 diabetic peripheral neuropathy group(DPN group),including 61 males and 48 females,with an average age of 55.82±11.33 years.The non-diabetic peripheral neuropathy group,namely the simple type 2 diabetes group(NDPN group)91 cases,including 60 males and 31 females,with an average age of 53.01±13.00 years.Collect the general information of these patients(including gender,age,height,weight,course of diabetes,blood pressure,etc.),laboratory indicators(including fasting blood glucose,liver and kidney function,blood lipids and glycosylated hemoglobin,etc.),oxidative stress indicators(including superoxide Dismutase and malondialdehyde),inflammatory indicators(including tumor necrosis factor-α),nerve conduction velocity(including median nerve sensory and motor conduction velocity,ulnar nerve sensory and motor conduction velocity,common peroneal nerve motor conduction velocity,superficial peroneal nerve Sensory conduction velocity)and serum FGF21,and compare the indicators between the two groups.Analyzing the correlation between serum FGF21 and various indicators by Pearson correlation,and the influencing factors of type 2 diabetic peripheral neuropathy by Logistic regression.Results 1 FGF21 in the DPN group(720.25±416.89)was significantly higher than that in the NDPN group(469.14±217.36),and the difference was statistically significant(P<0.05).The duration of type 2 diabetes mellitus,fasting blood glucose,glycated hemoglobin,urea nitrogen,uric acid,MDA,and TNF-α in the DPN group were significantly higher than those in the NDPN group(P<0.05),and SOD,sensory and motor nerve conduction velocities were significantly lower than those in the NDPN group(P<0.05).2 Correlation analysis showed that FGF21 was positively correlated with fasting blood glucose,glycated hemoglobin,MDA,and TNF-α(r=0.184,0.156,0.164,0.175,P<0.05),and was negatively correlated with SOD,median nerve motor conduction velocity,ulnar nerve motor conduction velocity,the sensory conduction velocity of the median nerve and the superficial peroneal nerve(r=-0.189,-0.161,-0.149,-0.155,-0.162,P<0.05).3 Logistic regression analysis showed that the duration of type 2 diabetes mellitus,MDA,FGF21 and TNF-α were independent risk factors for DPN(OR=1.499,1.242,1.007,1.036,P<0.05).Conclusions 1 The level of FGF21,MDA,and TNF-α in the serum of patients with type 2 diabetic peripheral neuropathy are elevated,and they are independent risk factors for the occurrence of DPN.2 FGF21 can protect DPN by regulating sugar metabolism,inhibiting oxidative stress and inflammation.Figure [0];Table [3];Reference [135]...